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Beta-Amylase CAS:9000-91-3 Theko ea moetsi
Beta-amylase ke enzyme e bapalang karolo ea bohlokoa metabolism ea lik'habohaedreite, haholo-holo ho qhalaneng kapa ho haelloang ha limolek'hule tsa starch. E susumetsa karohano ea litlamo tsa α-1,4-glycosidic ka har'a starch, e lokolla maltose le yuniti e nyane e bitsoang limit dextrin.
Enzyme ena e hlahisoa linthong tse fapaneng tse phelang, ho kenyeletsoa limela, libaktheria le li-fungus, 'me e sebelisoa haholo liindastering tse kang ho etsa biri, ho baka le tlhahiso ea biofuel.
Ha ho etsoa biri, beta-amylase e phetha karolo ea bohlokoa phetohong ea li-starche lijong tse malted ho ba tsoekere e belang nakong ea ts'ebetso ea ho sila, e tlatsetsa tlhahisong ea joala ka tomoso. Ha ho besoa, e thusa ho qhaqha li-starche hore e be tsoekere, e tlatsetsang ho soothong le nts'etsopele ea tatso ea lintho tse besitsoeng. Tlhahisong ea biofuel, beta-amylase e sebelisoa ho hydrolysis ea biomass e thehiloeng ho starch ho fumana tsoekere e belang e sebelisoang bakeng sa tlhahiso ea ethanol.
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Bromelain ho tsoa ho phaenapole STEM CAS:37189-34-7
Bromelain ke motsoako oa li-enzyme tse nkiloeng kutung ea semela sa phaenapole (Ananas comosus). E entsoe haholo-holo ka li-protease, e leng li-enzyme tse qhaqhang liprotheine. Bromelain e 'nile ea sebelisoa ka makholo a lilemo merianeng ea setso e le pheko ea tlhaho bakeng sa maemo a fapaneng a bophelo bo botle.
Ka lebaka la thepa ea eona ea ho sila protheine, bromelain hangata e sebelisoa e le thuso ea tšilo ea lijo, e thusang ho ntlafatsa ho senyeha le ho monngoa ha liprotheine tsamaisong ea tšilo ea lijo. E boetse e ithutiloe ka litlamorao tsa eona tsa ho thibela ho ruruha le melemo e ka bang teng ea ho fokotsa ho ruruha, ho longoa le bohloko.
Ntle le thepa ea eona ea tšilo ea lijo le ea ho thibela ho ruruha, bromelain e 'nile ea fuputsoa ka bokhoni ba eona lits'ebetsong tse ling tse fapaneng tsa phekolo, ho kenyeletsoa pholiso ea maqeba, tšehetso ea sesole sa 'mele le bophelo bo botle ba ho hema.
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Calpain Inhibitor IV CAS:133407-82-6
Calpain Inhibitor IV ke mofuta oa moriana o shebaneng le le ho thibela ka ho khetheha ts'ebetso ea enzyme calpain. Calpain ke enzyme ea protease e itšetlehileng ka calcium e bapalang karolo lits'ebetsong tse fapaneng tsa sele, ho kenyeletsoa le ho etsa hore lisele li sebetse hantle, ho apoptosis le ho nchafatsa cytoskeletal.
Ka ho thibela calpain, Calpain Inhibitor IV e thusa ho thibela ts'ebetso e feteletseng le e sa laoleheng ea enzyme ena, e leng se ka lebisang tšenyo ea sele le ho se sebetse hantle ha eona. Thibelo ena e ka ba molemo maemong ao ho 'ona calpain e sebetsang ho feta tekano, joalo ka mafu a methapo a kang mafu a Alzheimer's le Parkinson's, kotsi ea ischemic, kapa maemo a ho senyeha ha mesifa.
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Carboxypeptidase B CAS:9025-24-5
Carboxypeptidase B ke enzyme e bapalang karolo ea bohlokoa tšilong ea protheine le metabolism. Haholo-holo, e susumetsa hydrolysis ea libonto tsa peptide qetellong ea C-terminal ea liprotheine, e leng se fellang ka ho tlosoa ha li-amino acid ka bomong.
Carboxypeptidase B e ikhetha haholo bakeng sa li-amino acid tsa motheo, tse kang lysine le arginine, 'me e sebetsa haholo ho qhetsoleng masalla ana. E fumanoa hangata ho manyeng a pancreatic 'me e ameha mohatong oa ho qetela oa tšilo ea protheine ka maleng a manyenyane.
Enzyme ena e boetse e sebelisoa lits'ebetsong tse fapaneng tsa laboratori, ho kenyeletsoa tatellano ea protheine, tlhahiso ea peptide, le tlhahlobo ea protheine. Bokhoni ba carboxypeptidase B ba ho arola ka ho khetheha li-amino acid tsa C-terminal tsa liprotheine bo etsa hore e be sesebelisoa sa bohlokoa sa ho ithuta sebopeho le ts'ebetso ea protheine.
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Carboxypeptidase, dipeptidyl, A CAS:9015-82-1
Carboxypeptidase ke enzyme e susumetsang hydrolysis (ho senyeha) ha dibonto tsa peptide pheletsong ya carboxyl (C-terminal) ya dipeptide le diprotheine. E thusa tshilong ya dijo le tsamaisong ya diprotheine ka ho kgaola di-amino acid ka bomong pheletsong ya ketane ya peptide. Di-carboxypeptidase di arotswe ka mefuta e mmedi: di-exopeptidase, tse tlosang di-amino acid ka bonngoe pheletsong ya C-terminal, le di-endopeptidase, tse kgaolang dibonto tsa peptide ka hara ketane ya peptide. Di-enzyme tsena di bapala karolo ya bohlokwa mekgweng e fapaneng ya baeloji, ho kenyeletswa metabolism ya protheine, taolo ya dihormone, le taolo ya tshebetso ya enzymatic.
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Coenzyme A sodium salt hydrate CAS:55672-92-9
Coenzyme A sodium salt hydrate ke mofuta o qhibilihang ka metsing oa Coenzyme A (CoA), coenzyme ea bohlokoa e amehang litseleng tse fapaneng tsa metabolism. E bapala karolo ea bohlokoa ho heleng ha mafura, lik'habohaedreite le liprotheine, hammoho le ho qaptjoang ha limolek'hule tsa bohlokoa tse kang mafura a acid le k'holeseterole. Coenzyme A sodium salt hydrate e sebelisoa hangata lipatlisisong tsa biochemical le tsa meriana e le tlatsetso ho ithuta metabolism ea sele le lits'ebetso tse amanang le eona.
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5-Nitro-1,10-phenanthroline CAS:4199-88-6
5-Nitro-1,10-phenanthroline ke motsoako oa lik'hemik'hale o nang le foromo ea limolek'hule ea C12H6N4O2. Ke oa lelapa la li-derivatives tsa phenanthroline 'me o na le sehlopha sa nitro (-NO2) se hoketsoeng boemong ba 5 ba sistimi ea lesale la phenanthroline.
Motsoako ona o tsebahala ka bokhoni ba wona ba ho theha metsoako e tsitsitseng ka di-ion tsa tshepe, haholo-holo di-ion tsa tshepe tse fetohang. Sehlopha sa nitro se ntlafatsa thepa ya sona ya ho kopana mme se etsa hore e be le thuso ditshebedisong tse fapaneng tse kang khemistri ya tlhahlobo, catalysis, le khemistri ya kgokagano.
5-Nitro-1,10-phenanthroline e sebelisitsoe e le chelator, ho bolelang hore e theha maqhama a tsitsitseng le li-ion tsa tšepe ka ho fana ka lipara tse le 'ngoe tsa lielektrone. Sena se lumella taolo e nepahetseng le tsamaiso ea tikoloho ea tšebelisano ea li-ion tsa tšepe.
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Acetyl coenzyme A letsoai la sodium CAS:102029-73-2
Letswai la sodium la Acetyl coenzyme A (acetyl-CoA) ke ntho e entsoeng ka maiketsetso e tsoang ho acetyl-CoA. Hangata e sebelisoa lipatlisisong tsa laboratori le lithutong tsa biochemical.
Tšebeliso e ka sehloohong ea letsoai la sodium la acetyl-CoA e lithutong tsa metabolism ea sele, haholo-holo ho fuputseng karolo ea acetyl-CoA litseleng tse fapaneng tsa metabolism. Acetyl-CoA e sebetsa e le selelekela sa tlhahiso ea mafura a acid, k'holeseterole le 'mele ea ketone, hammoho le ho bapala karolo ea bohlokoa tlhahisong ea matla ka potoloho ea citric acid (e tsejoang hape e le potoloho ea Krebs).
Ho phaella moo, acetyl-CoA e ameha ho acetylation ea liprotheine, DNA le histones, tse ka amang tlhahiso ea liphatsa tsa lefutso le ho nchafatsoa ha chromatin. Ka hona, letsoai la sodium la acetyl-CoA le ka sebelisoa lithutong tse shebaneng le liphetoho tsena tsa epigenetic le tšusumetso ea tsona mosebetsing oa sele.
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Puromycin dihydrochloride CAS: 58-58-2 Theko ea moetsi
Puromycin dihydrochloride ke sebolaya-mafu se matla se sebediswang haholo dipatlisisong tsa baeloji ya dimolek'hule le baeloji ya disele. E thibela tlhahiso ya protheine ka ho baka ho kgaotsa ho etswa ha protheine pele ho nako nakong ya phetolelo. Puromycin e sebetsa hantle kgahlanong le disele tsa prokaryotic le eukaryotic mme e na le thuso haholo bakeng sa ho kgetha le ho arola disele tse fetotsweng ka lefutso kapa tse fetiseditsweng ka gene ya ho hanyetsa puromycin. Hangata e sebediswa dibakeng tsa laboratori ho ithuta tlhahiso ya lefutso, tlhahiso ya protheine, le ho hlahisa mela e tsitsitseng ya disele ka diphetoho tse ikgethang tsa lefutso.
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Acetylcholinesterase CAS:9000-81-1
Li-anticholinesterase ke sehlopha sa meriana kapa lik'hemik'hale tse thibelang ts'ebetso ea enzyme ea acetylcholinesterase. Acetylcholinesterase e ikarabella bakeng sa ho qhaqha acetylcholine ea neurotransmitter 'meleng. Ka ho thibela enzyme ena, li-anticholinesterase li eketsa maemo a acetylcholine, e leng se lebisang ho eketseheng ha ts'ebetso ea cholinergic tsamaisong ea methapo e bohareng le e ka ntle.
Tšebeliso e ka sehloohong ea meriana ea anticholinesterase ke kalafong ea mafu a methapo a kang lefu la Alzheimer le myasthenia gravis. Lefung la Alzheimer, meriana ena e ikemiselitse ho ntlafatsa phetisetso ea cholinergic neurotransmission le ho fokotsa ho fokotseha ha tsebo. Lefung la myasthenia gravis, anticholinesterases e thusa ho ntlafatsa phetisetso ea methapo le matla a mesifa.
Tšebeliso e 'ngoe ea li-anticholinesterase e kenyelletsa ho hlahloba le ho phekola chefo ea anticholinergic, haholo-holo ho tsoa ho likokoanyana tse itseng kapa metsoako ea methapo. Lintho tsena li ka baka ho hlasimoloha ho feteletseng ha li-receptor tsa muscarinic le nicotinic, e leng se lebisang matšoao a kang bofokoli ba mesifa, ho thothomela le ho hema hampe. Li-anticholinesterase li ka fetola liphello tsena ka ho eketsa maemo a acetylcholine le ho qothisana lehlokoa le lintho tse chefo.
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Rapamycin ho tsoa ho Streptomyces hygroscopicus CAS:53123-88-9
Rapamycin ke motsoako o hlahang ka tlhaho o arohantsoeng le baktheria ea Streptomyces hygroscopicus. E na le mesebetsi e mengata ea baeloji 'me e tsebahala haholo ka thepa ea eona ea ho thibela sesole sa' mele le ho loantša kankere.
Qalong e fumanoe e le sebolaya-mafu, rapamycin ho tloha ka nako eo e fumanoe e na le thepa e matla ea ho thibela sesole sa 'mele, e leng se etsang hore e be ea bohlokoa ho fetisetsoeng ha litho ho thibela ho lahloa. E etsa sena ka ho thibela ts'ebetso le ho ata ha lisele tsa T, e leng karolo ea bohlokoa ea karabelo ea 'mele ea ho itšireletsa mafung.
Ho phaella moo, rapamycin e bontšitse liphetho tse tšepisang kalafong ea mefuta e fapaneng ea kankere. E sebetsa ka ho thibela protheine e bitsoang mTOR (sepheo sa rapamycin sa mammalian), e bapalang karolo ea bohlokoa kholong le karohanong ea lisele. Ka ho thibela mTOR, rapamycin e thusa ho laola kholo e sa laoleheng ea lisele tsa kankere.
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Acylase ho tsoa ho mofuta oa Aspergillus CAS:9012-37-7
Acylase ke enzyme e hlahisoang ke mefuta e fapaneng ea mofuta oa Aspergillus, ho kenyeletsoa Aspergillus oryzae le Aspergillus niger. Enzyme ena ke ea lelapa la li-hydrolases 'me e ameha ho hydrolysis ea metsoako ea acyl.
Li-acylase li bapala karolo ea bohlokoa lits'ebetsong tse fapaneng tsa biochemical, haholo-holo metabolism ea metsoako ea lintho tse phelang. Li susumetsa karohano ea lihlopha tsa acyl ho tloha substrate, hangata li sebelisa metsi e le co-reactant. Karabelo ena ea enzymatic e tsejoa e le acyl hydrolysis.
Li-acylase tse tsoang mofuteng oa Aspergillus li ithutiloe ka botlalo 'me li sebelisitsoe lits'ebetsong tsa theknoloji ea baeloji. Li bontšitse bokhoni bo boholo tlhahisong ea metsoako e fapaneng ea bohlokoa joalo ka li-amino acid, lithibela-mafu le lintho tse ling tse kopanyang meriana.
