Acetylcholinesterase CAS:9000-81-1

Tšusumetso ea anticholinesterase e bolela bokhoni ba lithethefatsi kapa lik'hemik'hale tse itseng ho thibela ts'ebetso ea enzyme acetylcholinesterase. Acetylcholinesterase e ikarabella bakeng sa ho qhaqha acetylcholine ea neurotransmitter 'meleng. Ka ho thibela enzyme ena, anticholinesterase e eketsa maemo a acetylcholine, e leng se lebisang ho eketseheng ha ts'ebetso ea cholinergic.

Tšebeliso e ka sehloohong ea li-anticholinesterase ke kalafong ea maemo a khetholloang ke ts'ebetso e fokotsehileng ea cholinergic. Tsena li kenyelletsa mathata a methapo ea kutlo a kang lefu la Alzheimer le myasthenia gravis. Lefung la Alzheimer, li-anticholinesterase tse kang donepezil, rivastigmine, le galantamine li sebelisoa ho thibela ho senyeha ha acetylcholine le ho ntlafatsa phetisetso ea methapo ea kutlo ea cholinergic. Sena se ka thusa ho ntlafatsa ts'ebetso ea kelello le ho fokotsa tsoelo-pele ea lefu lena.

Ho myasthenia gravis, li-anticholinesterase tse kang neostigmine le pyridostigmine li sebelisoa ho ntlafatsa phetiso ea methapo ea kutlo. Meriana ena e thibela acetylcholinesterase le ho eketsa maemo a acetylcholine moo methapo ea kutlo e kopanang teng, e ntlafatsa matla a mesifa le ho fokotsa bofokoli ba mesifa.

Li-anticholinesterase li boetse li na le ts'ebeliso ea tlhahlobo le kalafo maemong a chefo ea anticholinergic. Metsoako ea anticholinergic, joalo ka likokoanyana tse itseng tse bolaeang likokoanyana kapa metsoako ea methapo, e ka baka thibelo e feteletseng ea cholinergic e lebisang matšoao a kang pherekano, ho otla ha pelo ka potlako, molomo o omileng le pono e lerootho. Maemong a joalo, li-anticholinesterase tse kang pralidoxime li ka sebelisoa ho fetola liphello ka ho eketsa maemo a acetylcholine le ho qothisana lehlokoa le lintho tse chefo.