4-Nitrophenyl Beta-D-glucuronide CAS:10344-94-2

Ho lemoha mosebetsi oa β-glucuronidase: 4-NPBG e atisa ho sebelisoa e le substrate ea chromogenic ho hlahloba boteng le mosebetsi oa β-glucuronidase ka mehlala e sa tšoaneng ea likokoana-hloko.Enzyme e senya tlamo ea glycosidic ea 4-NPBG, e hlahisa 4-nitrophenol, e ka lekanyetsoang ho sebelisa spectrophotometry.

Lithuto tsa metabolism ea lithethefatsi: Kaha β-glucuronidase e bapala karolo ea bohlokoa metabolism ea lithethefatsi le xenobiotics, 4-NPBG e ka sebelisoa ho lekola tšebetso ea enzyme ena lithutong tsa metabolism ea lithethefatsi.E thusa ho utloisisa boholo le kinetics ea karabelo ea glucuronidation, e bohlokoa bakeng sa tumello ea lithethefatsi le bioavailability.

Lithuto tsa Toxicology: Metsoako e meng ea chefo e ka fetoloa metabolized le ho ntšoa ka mokhoa oa li-conjugate tsa glucuronide.Ka ho sebelisa 4-NPBG e le substrate, bafuputsi ba ka hlahloba mosebetsi oa β-glucuronidase ka lisele tse fapaneng kapa liseleng tsa lisele ho hlahloba chefo e ka bang teng kapa liphello tse mpe tsa metsoako.

Tlhahlobo ea meriana: Tekanyo ea ts'ebetso ea β-glucuronidase e sebelisang 4-NPBG e ka sebelisoa maemong a kliniki ho hlahloba mafu kapa maemo a itseng.Maemo a sa tloaelehang kapa ts'ebetso ea β-glucuronidase e ka bonts'a mathata a itseng a lefutso, ho se sebetse ha sebete, kapa mofets'e.