Z-Pro-ONp CAS:3304-59-4

Z-Pro-ONp e sebelisoa haholo k'hemistring ea peptide e le sesebelisoa sa bohlokoa bakeng sa likarabelo tsa ho kopanya peptide le ho kopanya li-peptide le li-peptidomimetics. Jwalo ka derivative ea N-(p-nitrophenyl)oxycarbonyl (Npoc) ea L-proline, e nolofalletsa ho kenngoa ha masala a proline ka har'a liketane tsa peptide ka taolo e nepahetseng holim'a mehato ea ts'ireletso le ea ho tlosa ts'ireletso. Litsebi tsa lik'hemistri le bafuputsi ba itšetleha ka Z-Pro-ONp bakeng sa ho kopanya peptide ea mohato o tiileng le oa tharollo, e nolofalletsang kaho ea tatellano ea li-peptide tse ikhethileng tse etselitsoeng lipheo tse itseng tsa baeloji kapa merero ea kalafo. Ho feta moo, Z-Pro-ONp e fumana ts'ebeliso nts'etsopele ea li-peptidomimetics - limolek'hule tse etselitsoeng ho etsisa sebopeho le ts'ebetso ea li-peptide tse sebetsang. Ka ho kenyelletsa motifs tse tsoang ho Z-Pro-ONp ka har'a meaho ea peptidomimetic, bo-rasaense ba ka hlahloba metsoako e mecha e nang le lits'ebetso tse ka bang teng ho sibolloeng ha lithethefatsi, k'hemistri ea meriana le lipatlisiso tsa bongaka. Ho feta moo, Z-Pro-ONp e sebetsa e le motheo oa bohlokoa tlhahisong ea meriana le kalafo e thehiloeng ho peptide. Bohloeki ba eona bo phahameng le botsitso li etsa hore e be ea bohlokoa tlhahisong ea li-peptide le li-peptidomimetics tse ikhethileng bakeng sa lithuto tsa pele ho tleliniki le tsa bongaka, e fa bafuputsi monyetla oa ho rala le ho ntlafatsa meaho ea li-peptide ka ts'ebetso e ntlafalitsoeng ea baeloji le thepa ea pharmacokinetic. Ka kakaretso, Z-Pro-ONp e bapala karolo ea bohlokoa ho ntšetseng pele masimo a k'hemistri ea li-peptide, ho sibolloa ha lithethefatsi le nts'etsopele ea meriana, ho matlafatsa bo-rasaense le bafuputsi ho sebelisa bokhoni bo fapaneng ba li-peptide le li-peptidomimetics bakeng sa boqapi ba kalafo le saense.