Mofani oa Moetsi oa Simvastatin CAS:79902-63-9

Simvastatin ke ntho e entsoeng ka halofo, e sa rateng metsi haholo, e tšoanang le lovastatin. Joalo ka lovastatin, simvastatin ke thibelo e itseng ea HMG-CoA reductase 'me e sebelisoa kalafong ho fokotsa cholesterol ea LDL. Haufinyane tjena, li-statin li fetohile liphuputso tsa bohlokoa tsa biochemical baelojing ea sele. Ho kenella ha tsona liketsahalong tse ngata ho ka amahanngoa le mokhoa oa tsona oa mantlha oa ts'ebetso, leha ho le joalo, mokhoa oa ts'ebetso oa litlamorao tse ling tse ngata ha o bonahale haholo. Simvastatin ke thibelo e itseng ea HMG-CoA reductase, enzyme e susumetsang phetoho ea HMG-CoA ho mevalonate, mohato oa pele oa biosynthesis ea cholesterol. E sebelisoa kalafong ea hypercholesterolemia, kaha e fokotsa maemo a lipoprotein tse nang le density e tlase le triglycerides, 'me e phahamisa maemo a lipoprotein tse nang le density e phahameng.