Setmelanotide CAS:920014-72-8 Mofani oa Moetsi

Setmelanotide ke agonist ea melanocortin-4 receptor (MC4R). Tšebeliso ea eona e kenyelletsa kalafo ea mafu a itseng a liphatsa tsa lefutso a amanang le botenya, joalo ka khaello ea pro-opiomelanocortin (POMC), khaello ea leptin receptor (LEPR), le Bardet-Biedl syndrome. Setmelanotide e sebelisetsoa ho laola botenya bo feteletseng ho bakuli ba nang le maemo ana a itseng a liphatsa tsa lefutso, ka ho thusa ho laola takatso ea lijo le boima ba 'mele. Litla-morao tse tloaelehileng haholo li kenyelletsa liketso tsa sebaka sa ente, hyperpigmentation ea letlalo (libaka tsa letlalo tse lefifi ho feta letlalo le potolohileng), hlooho e opang le litla-morao tsa mala (tse kang ho nyekeloa ke pelo, letšollo le bohloko ba mpa), har'a tse ling. Ho ema ha botona ka tšohanyetso ho banna le liketso tse mpe tsa thobalano ho basali ho etsahetse ka kalafo. Ho tepella maikutlong le mehopolo ea ho ipolaea le tsona li etsahetse ka setmelanotide.