(R)-tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate CAS:955406-14-1

(R)-tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate e bapala karolo ea bohlokoa e le mokena-lipakeng oa metsoako e rarahaneng, e sebetsang ka lintho tse phelang e nang le lits'ebetso tse ka bang teng tsa meriana. Tlhaho ea eona ea chiral le likarolo tse ikhethang tsa sebopeho li e beha e le karolo ea bohlokoa bakeng sa ho thehoa ha metsoako ea enantiopure, e leng ea bohlokoa nts'etsopele ea meriana. Ka ho kenyelletsa letlooa lena la kaho ka har'a meralo ea limolek'hule, bafuputsi ba ka hlahloba bakhethoa ba meriana ba bacha ba shebaneng le libaka tsa kalafo tse kang mathata a tsamaiso ea methapo ea bohareng, mafu a tšoaetsanoang, kapa oncology. K'hemistri ea meriana, motsoako ona o ka sebetsa e le sebaka sa ho qala ho rala bakhethoa ba meriana ba ka bang teng, o sebelisa stereochemistry ea oona ho fetola ts'ebetso ea baeloji le thepa ea pharmacokinetic. Sehlopha sa tert-butyl se fana ka tšitiso ea steric mme se susumetsa likamano tsa motsoako le lipheo tsa baeloji, se kenya letsoho ho batlisiseng mekhoa e mecha ea phekolo. Ho feta moo, libakeng tsa thuto le tsa indasteri, bafuputsi ba ka sebelisa letlooa lena la kaho ho lokisa lilaebrari tsa lintho tse fapaneng tse tsoang ho tsona bakeng sa lithuto tsa kamano ea sebopeho le mosebetsi, ho nolofalletsa ho tsebahatsa metsoako ea loto e nang le litlamorao tse lakatsehang tsa baeloji. Karolo ea eona tlhahisong ea lik'hemik'hale e atolohela tlhahisong ea metsoako e kopanyang meriana le nts'etsopele ea mekhoa e mecha ea maiketsetso, e bonts'a thuso ea eona e pharaletseng mafapheng a saense. Ka kakaretso, (R)-tert-butyl 4,5,6,7-tetrahydro-1H-indazol-5-ylcarbamate e bapala karolo ea bohlokoa ho phehelleng ho sibolloa ha meriana e mecha le tlhahiso ea metsoako e sa lekanang, e fanang ka sethala sa nts'etsopele ea limolek'hule tse fapaneng tse sebetsang ka baeloji le metsoako e kopanyang ea meriana.