Clofibricacid CAS: 882-09-7

Asiti ea clofibric e na le lits'ebetso tse 'maloa tsa bohlokoa thutong ea meriana le bongaka. E 'ngoe ea ts'ebeliso ea eona ea mantlha ke e le moemeli oa hypolipidemic bakeng sa ho fokotsa maemo a phahameng a k'holeseterole le triglycerides maling. Asiti ea clofibric e sebetsa ka ho kenya tšebetsong li-receptor tse itseng tse amehang metabolism ea lipid, e leng se lebisang tlhahisong e fokotsehileng le keketseho ea ho putlama ha mafura 'meleng. Ntle le karolo ea eona taolong ea lipid, asiti ea clofibric e sebelisoa lithutong tsa mahlale ho batlisisa mekhoa ea ts'ebetso ea li-fibrate, sehlopha sa lithethefatsi tse tšoanang ka sebopeho le asiti ea clofibric. Bafuputsi ba ithuta litlamorao tsa pharmacological tsa asiti ea clofibric ho liprofaele tsa lipid, bophelo bo botle ba pelo le methapo ea mali le litsela tsa metabolism ho ntlafatsa maano a kalafo bakeng sa dyslipidemia le maemo a amanang le ona. Ho feta moo, motsoako ona o sebelisoa lipatlisisong tsa pele ho kliniki ho batlisisa melemo ea ona ea kalafo mathateng a fapaneng a metabolism, joalo ka hyperlipidemia, atherosclerosis le botenya. Ka ho lekola katleho le polokeho ea asiti ea clofibric mehlaleng ea liphoofolo le litso tsa lisele, bo-rasaense ba ikemiselitse ho sibolla temohisiso e ncha mabapi le taolo ea lipid le ho nts'etsapele mekhoa e mecha ea kalafo bakeng sa mafu a metabolism. Ho feta moo, clofibric acid e sebetsa e le sesebelisoa sa bohlokoa ho sibolloeng le nts'etsopele ea meriana, e fana ka motheo oa ho rala metsoako e mecha ea ho theola lipid le ho batlisisa thepa ea eona ea meriana. Litšebelisano tsa eona tsa biochemical le litlamorao tsa 'mele li kenya letsoho ho batlisiseng mekhoa ea phekolo e reretsoeng ho laola mabaka a kotsi a pelo le methapo ea mali le ho ntlafatsa liphetho tsa bophelo bo botle ka kakaretso. Ka kakaretso, clofibric acid e bapala karolo ea bohlokoa ho feto-fetoheng ha lipid, lipatlisisong tsa metabolism, le boqapi ba lithethefatsi, e totobatsa bohlokoa ba eona ho sebetsaneng le mathata a pelo le methapo ea mali le matšoao a metabolism. Tšusumetso ea eona metabolism ea lipid le bokhoni ba kalafo e totobatsa bohlokoa ba motsoako ho ntšetseng pele saense ea bongaka, mokhoa oa bongaka le merero ea bophelo bo botle ba sechaba.