(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride CAS:188416-35-5

(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride e sebediswa k'hemistring ya meriana bakeng sa mesebetsi ya yona e ka bang teng ya meriana le ditshebediso tsa kalafo. Motswako ona o ka bontsha thepa ya ho thibela ho ata ha dikokwana-hloko, ho thibela ho ruruha, kapa ho thibela dienzyme e thusang kalafong ya mafu a fapaneng, ho kenyeletswa kankere, ho ruruha le maemo a tshwaetsanang. Ha ho sibollwa meriana, bafuputsi ba sebedisa (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride ho rala le ho kopanya metswako e metjha e nang le matla a ntlafetseng, kgetho, le bioavailability. Ka ho fetola sebopeho sa yona sa dikhemikhale le ho hlahloba dikamano tsa sebopeho le tshebetso, bo-rasaense ba ikemiseditse ho ntshetsa pele di-agent tse ntjha tsa kalafo tse shebaneng le ditsela tse ikgethang tsa dimolek'hule le dipheo tsa baeloji tse amehang mafung. Ho feta moo, motswako ona o sebetsa e le scaffold ya dimolek'hule bakeng sa ho kopanya ba ka bang teng ba batlang meriana ka diprofaele tse ntlafaditsweng tsa pharmacokinetic le katleho e ntlafetseng ya kalafo. Litšebelisano tsa eona le lipheo tsa sele, litsela tsa lipontšo, le li-biomarker tsa lefu li fana ka temohisiso mabapi le litlamorao tsa eona tsa baeloji le mekhoa ea ts'ebetso, e tataisa nts'etsopele ea mekhoa ea phekolo e reretsoeng le kalafo e ikhethileng bakeng sa bakuli ba nang le litlhoko tsa bongaka tse sa fihlellehang. Ho feta moo, (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride e ka sebelisoa lithutong tsa pele ho tleliniki ho lekola polokeho ea eona, katleho le thepa ea meriana pele e fetela litekong tsa bongaka. Mosebetsi oa eona oa bio, litlamorao tsa meriana, le litla-morao tse ka bang teng li hlahlojoa ho fumana bokhoni ba eona ba kalafo le ho tšoaneleha bakeng sa nts'etsopele e tsoelang pele joalo ka sehlahisoa sa meriana. Ka kakaretso, (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride e emela motsoako oa bohlokoa lipatlisisong tsa k'hemistri ea meriana, e fanang ka menyetla ea ho sibolla meriana, ntlafatso ea tataiso, le boqapi ba kalafo boitekong ba ho sebetsana le maemo a rarahaneng a bongaka le ho ntlafatsa liphetho tsa bakuli.