(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one CAS:32384-65-9

E entsoe ka mekhoa ea lik'hemik'hale tsa tlhaho, (3R, 4S, 5R, 6R)-3, 4, 5-tris (trimethylsilyloxy)-6-((trimethylsilyloxy)methyl) tetrahydro-2H-pyran-2-one e bonts'a litšobotsi tse ikhethang tsa sebopeho tse bohlokoa bakeng sa lits'ebetso tsa eona tse fapaneng. Lesale la tetrahydropyran, hammoho le lihlopha tsa trimethylsilyloxy, le susumetsa boitšoaro ba lona ba lik'hemik'hale le likamano tse ka bang teng le limolek'hule tse ling. Litšebeliso ho Meriana Motsoako ona o bontša tšepiso lipatlisisong tsa meriana ka lebaka la mekhoa ea eona ea sebopeho. Li-derivatives tsa Pyranone li tsebahala ka mesebetsi ea tsona e fapaneng ea meriana, joalo ka thepa ea antiviral, antifungal, le anticancer. Boteng ba lihlopha tse ngata tsa trimethylsilyloxy bo ka fetola ho qhibiliha ha eona, botsitso le bioavailability, ho ama bokhoni ba eona ba kalafo. Mesebetsi ea Baeloji le Mekhoa Patlisiso e fana ka maikutlo a hore li-derivatives tsa pyranone li ka sebelisana le litsamaiso tsa baeloji ka lebaka la ho tšoana ha tsona le metsoako ea tlhaho. Lihlopha tsa trimethylsilyloxy li ka kenya letsoho litšobotsing tse itseng tsa meriana, tse ka 'nang tsa susumetsa mokhoa oa eona oa ketso le litsela tsa metabolism. Ho utloisisa mekhoa ena ho bohlokoa bakeng sa ho ntlafatsa litlamorao tsa eona tsa kalafo. Litsela le Nts'etsopele ea Maiketsetso Ho kopanngoa ha (3R,4S,5R,6R)-3,4,5-tris (trimethylsilyloxy)-6-((trimethylsilyloxy)methyl)tetrahydro-2H-pyran-2-one ho kenyelletsa lits'ebetso tse rarahaneng tsa tlhaho tse qalang ho tsoa thepa ea ho qala e fumanehang khoebong. Ho lokisa litsela tsa maiketsetso hantle ho bohlokoa ho fihlella bohloeki bo phahameng, chai, le ho hola ho hlokahalang bakeng sa tlhahiso ea indasteri le lits'ebetso tsa meriana. Lipatlisiso tsa Hona Joale le Litaelo tsa Nakong e Tlang Phuputso e tsoelang pele e ikemiselitse ho hlahloba mefuta eohle ea mesebetsi ea baeloji ea motsoako, ho kenyeletsoa le bokhoni ba oona e le moemeli oa antiviral le karolo ea oona kalafong ea mofetše. Lithuto tsa nakong e tlang li ka shebana le liphetoho tsa sebopeho ho ntlafatsa boemo ba eona ba meriana le mafu a itseng a reretsoeng ka katleho. Ho feta moo, lipatlisiso mabapi le ts'ebeliso ea eona e le setsi sa maiketsetso se feto-fetohang k'hemistri ea lintho tse phelang li ntse li tsoela pele. Qetellong, (3R,4S,5R,6R)-3,4,5-tris (trimethylsilyloxy)-6-((trimethylsilyloxy)methyl)tetrahydro-2H-pyran-2-one e emela motsoako oa bohlokoa k'hemistri ea lintho tse phelang le lipatlisiso tsa meriana. Litšobotsi tsa eona tse ikhethang tsa sebopeho le mesebetsi e ka bang teng ea meriana li etsa hore e be taba ea lipatlisiso tsa saense le boqapi bo tsoelang pele, e nang le tšepiso bakeng sa lits'ebetso tse fapaneng saenseng ea bongaka le thepa. Ho utloisisa tlhahiso ea eona, likamano tsa baeloji le bokhoni ba kalafo ke habohlokoa bakeng sa ho sebelisa melemo ea eona masimong a fapaneng.