1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID CAS:113100-53-1

1-Methyl-3- (trifluoromethyl)-1H-pyrazole-4-carboxylic acid e hlahisoa ka mekhoa ea lik'hemik'hale tsa tlhaho, e kenyeletsang liketso tse hlahisang liathomo tsa fluorine le sehlopha sa methyl mokokotlong oa pyrazole. Molek'hule e hlahisoang e na le litšobotsi tse ikhethang tsa sebopeho tse bohlokoa bakeng sa lits'ebetso tsa eona tse reriloeng saenseng ea meriana le lik'hemik'hale. Litšebeliso ho Meriana Motsoako ona o bontša bokhoni bo tšepisang ba meriana bo bakoang ke motifs ea oona ea sebopeho. Li-derivatives tsa pyrazole li tumme ka mesebetsi ea tsona e fapaneng ea meriana, ho tloha ho antimicrobial ho isa ho thepa ea antitumor. Ho kenyelletsoa ha sehlopha sa trifluoromethyl ho ka fetola haholo ts'ebetso ea baeloji le botsitso ba metabolism, e leng se ka ntlafatsang katleho ea lithethefatsi le liprofaele tsa polokeho. Mesebetsi ea Baeloji le Mekhoa ea Baeloji Lipatlisiso li bontša hore metsoako e nkeloang sebaka ke trifluoromethyl hangata e bonts'a lipophilicity e ntlafalitsoeng le ho hanyetsa metabolism, e amang thepa ea eona ea ho monya, kabo, metabolism le excretion (ADME). Liphetoho tsena li ka lebisa ho ntlafatso ea bioavailability le litlamorao tsa kalafo tse telele, e leng se etsang hore e be bakhethoa ba khahlehang bakeng sa nts'etsopele ea lithethefatsi. Mekhoa le Nts'etsopele ea Maiketsetso Ho kopanngoa ha 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ho kenyelletsa lits'ebetso tsa mehato e mengata ho qala ka thepa ea ho qala e fumanehang khoebong. Ntlafatso ea mekhoa ea maiketsetso e ikemiselitse ho ntlafatsa chai, bohloeki le ho hola, e leng tsa bohlokoa bakeng sa lits'ebetso tsa indasteri le tlhahiso e kholo libakeng tsa meriana. Lipatlisiso tsa Hona Joale le Litaelo tsa Nakong e Tlang Phuputso e tsoelang pele e shebane le ho hlakisa mefuta eohle ea mesebetsi ea baeloji e amanang le 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid. Sena se kenyelletsa ho lekola katleho ea eona khahlanong le lipheo tse itseng tsa lefu le ho ntlafatsa mekhoa ea liteko tsa kliniki. Lithuto tsa nakong e tlang li ka hlahloba bokhoni ba eona e le sebopeho sa motheo sa ho rala bakhethoa ba meriana ba bacha ba nang le liprofaele tsa meriana tse ikhethileng. Ka kakaretso, 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid e emela tsoelo-pele e kholo k'hemistri ea meriana. Thepa ea eona e ikhethang ea sebopeho le mesebetsi e ka bang teng ea meriana li totobatsa bohlokoa ba eona e le taba ea lipatlisiso tse tsoelang pele tsa saense le boqapi nts'etsopele ea meriana.