1-Hydroxybenzotriazolehydrate CAS:123333-53-9

1-Hydroxybenzotriazole hydrate e bapala karolo ea bohlokoa tlhahisong ea lintho tse phelang, haholo-holo lefapheng la k'hemistri ea peptide. E sebetsa e le sesebelisoa se sebetsang sa ho kopanya, se thusang ho thehoeng ha litlamo tsa peptide pakeng tsa li-amino acid nakong ea tlhahiso ea li-peptide le liprotheine. Bokhoni bona bo e etsa karolo ea bohlokoa tlhahisong ea meriana, li-bioconjugates, le metsoako e meng e sebetsang ka baeloji, e tlatsetsang tsoelo-peleng masimong a bongaka le theknoloji ea baeloji. Ho feta moo, 1-Hydroxybenzotriazole hydrate e sebelisoa haholo nts'etsopele ea lik'hemik'hale le thepa e ikhethang. Tšebeliso ea eona e akaretsa liindasteri tse fapaneng, ho kenyeletsoa meriana, lik'hemik'hale tsa temo le saense ea thepa, moo e kenyang letsoho tlhahisong ea limolek'hule tse rarahaneng tsa lintho tse phelang le ho thehoa ha lintho tse ncha tsa lik'hemik'hale tse nang le thepa e ikhethileng. Sena se beha motsoako e le mohloli oa bohlokoa bakeng sa ho holisa pokello ea li-block tsa kaho tsa lik'hemik'hale tse fumanehang le ho ntlafatsa boholo ba mefuta-futa ea lik'hemik'hale e fumanehang ho bafuputsi le bahlahisi. Ntle le bohlokoa ba eona k'hemistring ea lintho tse phelang le ea meriana, 1-Hydroxybenzotriazole hydrate e boetse e na le bohlokoa boitekong ba lipatlisiso tsa thuto le tsa indasteri. Karolo ea eona ho nolofatseng liphetoho tsa bohlokoa tsa lik'hemik'hale le ho nolofalletsa ho thehoa ha li-amide bond ka katleho e hapile tlhokomelo sechabeng sa mahlale, e leng se etsang hore lipatlisiso li etsoe ka mekhoa e mecha ea maiketsetso, mekhoa ea karabelo le lits'ebetso tsa lik'hemik'hale. Ho feta moo, ts'ebeliso ea eona libakeng tsa indasteri e tšehetsa ntlafatso ea lits'ebetso tsa tlhahiso le nts'etsopele ea lihlahisoa tse ncha, e totobatsa tšusumetso ea eona boqaping ba indasteri le tlhahiso. Ho feta moo, thepa e ikhethang ea motsoako e etsa hore e be mokhethoa ea khahlehang oa ho batlisisa lithutong tsa motheo tsa lik'hemik'hale, moo boitšoaro ba eona le karabelo ea eona li tlatsetsang kutloisisong ea melao-motheo le mekhoa ea lik'hemik'hale. Ka ho sebetsa e le sesebelisoa se feto-fetohang bakeng sa litsebi tsa lik'hemik'hale le bafuputsi, 1-Hydroxybenzotriazole hydrate e ntse e tsoela pele ho ntlafatsa tikoloho ea saense ea lik'hemik'hale le lits'ebetso tsa indasteri, e khothalletsa tsoelo-pele le boqapi libakeng tse ngata.