1-Hydroxybenzotriazole CAS:2592-95-2

1-Hydroxybenzotriazole, e leng reagent ea bohlokoa k'hemistring ea lintho tse phelang, e bapala karolo ea bohlokoa tšimong ea tlhahiso ea peptide. Tšebeliso ea eona e le moemeli oa ho kopanya ho thehoeng ha maqhama a peptide e nolofalletsa tlhahiso e sebetsang le e khethiloeng ea li-peptide le liprotheine, e tlatsetsa haholo nts'etsopele ea meriana, li-bioconjugates, le metsoako e amanang le eona e sebetsang ka baeloji. Sena se totobatsa karolo ea eona ea bohlokoa ho ntšetseng pele k'hemistri ea meriana le theknoloji ea baeloji, moo tlhahiso ea mekhoa ea phekolo le limolek'hule tse thehiloeng ho peptide e leng ea bohlokoa ka ho fetisisa. Ho feta moo, 1-Hydroxybenzotriazole e sebelisoa haholo ho lokiseng lik'hemik'hale le thepa e ikhethang, e tšehetsa liindasteri tse fapaneng tse kang meriana, lik'hemik'hale tsa temo le saense ea thepa. Ho kenella ha eona tlhahisong ea limolek'hule tse rarahaneng tsa lintho tse phelang le phetoho ea meaho ea lik'hemik'hale ho kenya letsoho nts'etsopele ea lik'hemik'hale tse ncha tse nang le thepa e etselitsoeng eona, ho ntlafatsa mefuta-futa le ts'ebetso ea li-block tsa kaho tsa lik'hemik'hale tse fumanehang. Sena, ka lehlakoreng le leng, se khothalletsa boqapi le tsoelo-pele ho thehoeng ha thepa e tsoetseng pele le lihlahisoa tsa lik'hemik'hale. Ho feta moo, thuso ea motsoako e atolohela lipatlisisong tsa thuto le tsa indasteri, moo karolo ea eona e le reagent e feto-fetohang e khannang lipatlisiso mekhoeng ea maiketsetso, mekhoa ea karabelo le lits'ebetso tsa lik'hemik'hale. Bokhoni ba eona ba ho thusa ho fetola dikhemikhale tsa bohlokwa le ho thehwa ha maqhama a amide bo hapile tlhokomelo setjhabeng sa mahlale, bo sebeletsa e le sesosa sa kgatelopele k'hemistring ya maiketsetso le boenjiniere ba dikhemikhale. Ho feta moo, dibakeng tsa diindasteri, 1-Hydroxybenzotriazole e tshehetsa ntlafatso ya ditshebetso tsa tlhahiso le ntshetsopele ya dihlahiswa tse ntjha, e kenya letsoho boqaping ba diindasteri le tlhahiso. Ho feta moo, thepa e ikgethang ya 1-Hydroxybenzotriazole e etsa hore e be mokgethi ya kgahlehang bakeng sa ho batlisisa dithutong tsa motheo tsa dikhemikhale, moo boitshwaro ba yona le karabelo ya yona di fanang ka temohisiso mabapi le melaomotheo le mekgwa ya dikhemikhale. Jwalo ka sesebediswa se feto-fetohang le sa bohlokwa bakeng sa dikhemistri le bafuputsi, 1-Hydroxybenzotriazole e tswela pele ho ntlafatsa tikoloho ya saense ya dikhemikhale le ditshebediso tsa diindasteri, e kgothaletsa kgatelopele le boqapi dibakeng tse ngata.