1-Butanone, 2-(dimethylamino)-2-(4-methylphenyl)methyl-1-4-(4-morpholinyl)phenyl- CAS:119344-86-4

Boteng ba sehlopha sa dimethylamino bo dumella ho qhibilihisa ho eketsehileng le ho sebelisana ho ka bang teng le li-receptor kapa li-enzyme tsamaisong ea baeloji. Motsoako oa lihlopha tsa 4-methylphenyl le morpholinyl o fana ka likarolo tse ling tsa sebopeho tse ka susumetsang thepa ea meriana ea motsoako. Likarolo tsena li kenya letsoho bokhoning ba motsoako e le molek'hule e etellang pele kapa mokena-lipakeng ho sibolloeng ha lithethefatsi. 1-Butanone, 2-(dimethylamino)-2-(4-methylphenyl)methyl-1-4-(4-morpholinyl)phenyl- e fumana lits'ebetso k'hemistring ea meriana ka lebaka la bokhoni ba eona ba ho sebelisana le liprotheine kapa li-receptor tse itseng tse reriloeng. E ka sebelisoa e le thepa ea ho qala bakeng sa ho kopanya li-analog kapa li-derivatives tse nang le matla a ntlafetseng, khetho, kapa thepa ea pharmacokinetic. Lihlopha tse fapaneng tsa ts'ebetso ea motsoako li fana ka menyetla ea liphetoho tse ling le ntlafatso ea mesebetsi e lakatsehang ea baeloji. Ntle le bokhoni ba eona ba meriana, motsoako ona o ka boela oa sebelisoa libakeng tse ling tsa mahlale. Sebopeho sa oona se rarahaneng se etsa hore o lokele lithuto tse kenyeletsang likamano tsa sebopeho le ts'ebetso, mohlala oa limolek'hule, le k'hemistri ea k'homphieutha. Ka ho utloisisa likamano pakeng tsa motsoako ona le limolek'hule tsa oona tse reriloeng, bafuputsi ba ka fumana temohisiso mabapi le mekhoa ea motheo ea ts'ebetso le ho nts'etsapele maano a macha a ho kenella kalafong. Ho feta moo, 1-Butanone, 2-(dimethylamino)-2-(4-methylphenyl)methyl-1-4-(4-morpholinyl)phenyl- e ka ba le lits'ebetso tse fetang k'hemistri ea meriana. Litšobotsi tsa eona tse ikhethang tsa sebopeho li etsa hore e be motsoako o khahlisang bakeng sa saense ea thepa, haholo-holo nts'etsopele ea thepa e sebetsang kapa li-polymer. Ho hlahisoa ha mefuta e fapaneng joalo ea lihlopha tse sebetsang molek'huleng e le 'ngoe ho bula menyetla ea thepa e entsoeng ka mokhoa o ikhethileng e nang le thepa e ikhethang, joalo ka litšobotsi tsa mahlo, tsa motlakase, kapa tsa mechini. Qetellong, 1-Butanone, 2-(dimethylamino)-2-(4-methylphenyl)methyl-1-4-(4-morpholinyl)phenyl- ke motsoako o rarahaneng o nang le bokhoni bo boholo k'hemistring ea meriana, ho sibolloa ha lithethefatsi le saense ea thepa. Sebopeho sa eona se rarahaneng, se kopanyang lihlopha tse fapaneng tse sebetsang, se fana ka ho tenyetseha le menyetla ea liphetoho tse ling le ntlafatso ea thepa e lakatsehang. Ka ts'ebeliso ea eona e fapaneng, motsoako ona o emela sesebelisoa sa bohlokoa bakeng sa bafuputsi ba batlang mekhoa e mecha ea phekolo, lisebelisoa tse sebetsang le tsoelo-pele ea mahlale.