β-Nicotinamide Mononucleotide CAS:1094-61-7

β-Nicotinamide mononucleotide (NMN) e sebedisetswa ho ithuta di-motif tse tlamang ka hara di-aptamers tsa RNA le mekgwa ya ho kenya tshebetsong ribozyme e kenyeletsang dikotwana tsa RNA tse sebetsang tsa β-nicotinamide mononucleotide (β-NMN). NMN ke nucleotide e tswang ho ribose le nicotinamide. Niacinamide (nicotinamide,) ke se tswang ho vithamine B3, e tsejwang hape e le niacin.) Jwalo ka selelekela sa dikhemikhale sa NAD+, e ka ba molemo ho thibeleng pellagra.
β-Nicotinamide mononucleotide ke karolo e bohareng ba biosynthesis ea nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) e susumetsa condensation ea nicotinamide ka 5-phosphoribosyl-1-pyrophosphate ho hlahisa β-NMN, eo hamorao e fetoloang ho NAD+ ke β-NMN adenyltransferase. Ho 50-100 μM, β-NMN e sebelisitsoe ho ntlafatsa biosynthesis ea NAD le tlhahiso ea insulin e susumetsoang ke glucose mohlaleng oa Nampt+/- oa lefu la metabolism, e leng se bontšang karolo ea Nampt mosebetsing oa sele ea β.