Z-Pro-NH2 CAS:34079-31-7

Z-Pro-NH2 e na le bohlokoa bo boholo k'hemistring ea peptide bakeng sa ho thehoa ha li-peptide le li-peptidomimetics. Jwalo ka derivative ea L-proline amide e sirelelitsoeng ke N-Boc, e nolofalletsa ho kenngoa ha masala a proline ka har'a liketane tsa peptide, e lumellang moralo oa tatellano ea li-peptide tse ikhethileng tse nang le thepa e itseng ea sebopeho le ea ts'ebetso. Litsebi tsa lik'hemistri le bafuputsi ba itšetleha ka Z-Pro-NH2 ka har'a motsoako oa peptide ea mohato o tiileng le oa mohato oa tharollo ho kenyelletsa motifs ea proline, e nolofalletsang ho batlisisa meaho e mecha ea peptide bakeng sa likamano tse reretsoeng le li-receptor tsa baeloji, li-enzyme le lipheo tse ling tsa biomolecular. Ho feta moo, Z-Pro-NH2 e fumana ts'ebeliso nts'etsopele ea li-peptidomimetics - limolek'hule tse etselitsoeng ho etsisa thepa le mesebetsi ea li-peptide tse sebetsang. Ka ho sebelisa likarolo tse tsoang ho Z-Pro-NH2, bo-rasaense ba ka etsa li-peptidomimetics tse nang le liprofaele tse fapaneng tsa meriana, ba fana ka bokhoni e le bakhethoa ba meriana ba bacha, li-probe tsa limolek'hule, le lisebelisoa tsa biochemical bakeng sa lits'ebetso tsa kalafo le lipatlisiso. Ho feta moo, Z-Pro-NH2 e sebetsa e le karolo ea bohlokoa tlhahisong ea meriana le meriana e thehiloeng ho peptide. Bohloeki ba eona bo phahameng le botšepehi li etsa hore e be ea bohlokoa tlhahisong ea li-peptide tse ikhethileng le li-peptidomimetics bakeng sa lithuto tsa pele ho tleliniki le tsa bongaka, e fa bafuputsi monyetla oa ho fetola meaho ea li-peptide ho fihlela ts'ebetso e ntlafalitsoeng ea baeloji, khetho le thepa ea pharmacokinetic. Ka bokhutšoanyane, Z-Pro-NH2 e kenya letsoho haholo ntlafatsong ea k'hemistri ea peptide, ho sibolloa ha lithethefatsi le nts'etsopele ea meriana, e fa bo-rasaense le bafuputsi mekhoa ea ho sebelisa bokhoni ba li-peptide le li-peptidomimetics bakeng sa ho sebetsana le liphephetso tse rarahaneng tsa baeloji le ho khanna boqapi ba kalafo.