ZD-Pro-OH CAS: 6404-31-5

ZD-Pro-OH e sebelisoa haholo k'hemistring ea peptide bakeng sa kaho ea li-peptide le li-peptidomimetics. Jwalo ka derivative ea D-proline e sirelelitsoeng ke N-tert-butoxycarbonyl (Boc), e nolofalletsa ho kenyelletsoa ha masala a D-proline ka har'a liketane tsa peptide, e fana ka sebopeho se ikhethang sa stereochemical se nang le lits'ebetso tse ka bang teng ho ntlafatseng ts'ebetso ea baeloji le botsitso ba metabolism. Litsebi tsa lik'hemistri le bafuputsi ba sebelisa ZD-Pro-OH ho kopanyeng peptide ea mohato o tiileng le mohato oa tharollo ho hlahisa motifs ea D-proline, e nolofalletsang moralo oa meaho e mecha ea peptide bakeng sa likamano tse shebaneng le li-receptor tsa baeloji le li-enzyme. Ntle le karolo ea eona ho kopanyeng peptide, ZD-Pro-OH e bohlokoa haholo nts'etsopele ea li-peptidomimetics - limolek'hule tse etselitsoeng ho etsisa thepa le mesebetsi ea li-peptide tse sebetsang. Ka ho kenyelletsa likarolo tse tsoang ho ZD-Pro-OH, bo-rasaense ba ka hlahloba ho bōptjoa ha li-peptidomimetics tse nang le liprofaele tse fapaneng tsa meriana, ba bula tsela bakeng sa bakhethoa ba meriana ba bacha, li-probe tsa limolek'hule, le lisebelisoa tsa biochemical tse nang le lits'ebetso tse ka bang teng tsa kalafo le lipatlisiso. Ho feta moo, ZD-Pro-OH e sebetsa e le karolo ea bohlokoa tlhahisong ea meriana le meriana e thehiloeng ho peptide. Bohloeki ba eona bo phahameng le botšepehi li etsa hore e be ea bohlokoa tlhahisong ea li-peptide tse ikhethileng le li-peptidomimetics bakeng sa lithuto tsa pele ho tleliniki le tsa bongaka, e fa bafuputsi monyetla oa ho qapa meaho ea li-peptide ka matla a ntlafalitsoeng a baeloji, khetho le thepa ea pharmacokinetic. Ka kakaretso, ZD-Pro-OH e bapala karolo ea bohlokoa ho ntšetseng pele masimo a k'hemistri ea peptide, ho sibolloa ha lithethefatsi le nts'etsopele ea meriana, ho fa bo-rasaense le bafuputsi lisebelisoa tsa ho notlolla bokhoni ba li-peptide le li-peptidomimetics bakeng sa ho sebetsana le liphephetso tse rarahaneng tsa baeloji le ho ntšetsa pele boqapi ba kalafo.

ZD-Pro-OH e sebelisoa haholo k'hemistring ea peptide bakeng sa kaho ea li-peptide le li-peptidomimetics. Jwalo ka derivative ea D-proline e sirelelitsoeng ke N-tert-butoxycarbonyl (Boc), e nolofalletsa ho kenyelletsoa ha masala a D-proline ka har'a liketane tsa peptide, e fana ka sebopeho se ikhethang sa stereochemical se nang le lits'ebetso tse ka bang teng ho ntlafatseng ts'ebetso ea baeloji le botsitso ba metabolism. Litsebi tsa lik'hemistri le bafuputsi ba sebelisa ZD-Pro-OH ho kopanyeng peptide ea mohato o tiileng le mohato oa tharollo ho hlahisa motifs ea D-proline, e nolofalletsang moralo oa meaho e mecha ea peptide bakeng sa likamano tse shebaneng le li-receptor tsa baeloji le li-enzyme. Ntle le karolo ea eona ho kopanyeng peptide, ZD-Pro-OH e bohlokoa haholo nts'etsopele ea li-peptidomimetics - limolek'hule tse etselitsoeng ho etsisa thepa le mesebetsi ea li-peptide tse sebetsang. Ka ho kenyelletsa likarolo tse tsoang ho ZD-Pro-OH, bo-rasaense ba ka hlahloba ho bōptjoa ha li-peptidomimetics tse nang le liprofaele tse fapaneng tsa meriana, ba bula tsela bakeng sa bakhethoa ba meriana ba bacha, li-probe tsa limolek'hule, le lisebelisoa tsa biochemical tse nang le lits'ebetso tse ka bang teng tsa kalafo le lipatlisiso. Ho feta moo, ZD-Pro-OH e sebetsa e le karolo ea bohlokoa tlhahisong ea meriana le meriana e thehiloeng ho peptide. Bohloeki ba eona bo phahameng le botšepehi li etsa hore e be ea bohlokoa tlhahisong ea li-peptide tse ikhethileng le li-peptidomimetics bakeng sa lithuto tsa pele ho tleliniki le tsa bongaka, e fa bafuputsi monyetla oa ho qapa meaho ea li-peptide ka matla a ntlafalitsoeng a baeloji, khetho le thepa ea pharmacokinetic. Ka kakaretso, ZD-Pro-OH e bapala karolo ea bohlokoa ho ntšetseng pele masimo a k'hemistri ea peptide, ho sibolloa ha lithethefatsi le nts'etsopele ea meriana, ho fa bo-rasaense le bafuputsi lisebelisoa tsa ho notlolla bokhoni ba li-peptide le li-peptidomimetics bakeng sa ho sebetsana le liphephetso tse rarahaneng tsa baeloji le ho ntšetsa pele boqapi ba kalafo.