VALINOMYCIN CAS:2001-95-8 Theko ea moetsi

Valinomycin e sebetsa haholo-holo e le ionophore, ho bolelang hore e nolofalletsa ho tsamaisoa ha li-ion tse itseng ho pholletsa le lera la sele. Tšusumetso ea eona e ikhethang haholo ke kamano ea eona e matla le li-ion tsa potassium (K+). Valinomycin e theha motsoako o nang le li-ion tsa K+, e leng se etsang hore e khethe haholo bakeng sa ho tsamaisoa ha tsona.

E 'ngoe ea lits'ebetso tse ka sehloohong tsa valinomycin ke e le ionophore lielektrodeng tse khethang li-ion bakeng sa ho lekanya mahloriso a potasiamo lisampoleng tsa baeloji. Lielektrode tsena li sebelisa bokhoni ba valinomycin ba ho tlama le ho tsamaisa li-ion tsa K+ ka mokhoa o ikhethileng, ho nolofalletsa litekanyo tse nepahetseng le tse bonolo tsa li-ion tsa potasiamo.

Bokhoni ba Valinomycin ba ho tsamaisa li-ion tsa potassium bo boetse bo etsa hore e be ea bohlokoa lipatlisisong tse amanang le ho tsamaisoa ha li-ion le bokhoni ba lera ka har'a lisele. E sebelisoa ho ithuta karolo ea likanale tsa li-ion, bokhoni ba lera, le li-gradients tsa li-ion lits'ebetsong tse fapaneng tsa baeloji.

Ho feta moo, valinomycin e 'nile ea fuputsoa bakeng sa ts'ebeliso ea eona e ka bang teng ea phekolo. E bontšitse liphetho tse tšepisang e le moemeli oa anticancer mefuteng e itseng ea kankere. Valinomycin e baka apoptosis (lefu la sele) liseleng tsa kankere ka ho sitisa bokhoni ba tsona ba lera la mitochondrial.