Uridine-5′-diphosphoglucuronic acid letswai la trisodium CAS: 63700-19-6

Ho tlosa chefo: UDP-glucuronic acid ke molek'hule ea bohlokoa e amehang liketsong tsa phetoho ea bio ea karolo ea II ea xenobiotics le metsoako ea tlhaho. E sebetsa e le selelekela sa tlhahiso ea glucuronides, e leng li-conjugate tse qhibilihang ka metsing tse ka tlosoang habonolo 'meleng. Ts'ebetso ena ea ho tlosa chefo e thusa ho fokotsa le ho felisa lintho tse ka bang kotsi, tse kang lithethefatsi, chefo ea tikoloho, le lihlahisoa tse ling tsa metabolism.

Metabolism ea lithethefatsi: Meriana e mengata e feta glucuronidation, e leng mokhoa oo UDP-glucuronic acid e kopanang le molek'hule ea lithethefatsi, e leng se fellang ka ho thehoa ha metabolite ea glucuronide. Karabelo ena ea glucuronidation hangata e ntlafatsa ho tlosoa ha lithethefatsi 'meleng le ho nolofalletsa ho ntšoa ha tsona ka moroto kapa bile. Letsoai la trisodium la UDP-glucuronic acid le sebelisoa khafetsa lithutong tse batlisisang metabolism le pharmacokinetics ea lithethefatsi.

Sesebelisoa sa lipatlisiso: UDP-glucuronic acid Letswai la trisodium le sebelisoa haholo e le sesebelisoa sa lipatlisiso lithutong tse fapaneng tse amanang le metabolism ea lithethefatsi, enzymology, le toxicology. E fana ka mohloli oa UDP-glucuronic acid bakeng sa liteko tsa in vitro 'me e nolofalletsa bafuputsi ho batlisisa tšusumetso ea glucuronidation ho hlephisong ea lithethefatsi, ho fumaneha ha tsona 'meleng, le likamano tse ka bang teng pakeng tsa lithethefatsi le lithethefatsi.

Glycosylation: Asiti ea UDP-glucuronic e boetse e ameha liketsong tsa glycosylation, moo e sebetsang e le mofani oa likarolo tsa glucuronic acid bakeng sa ho kopanya li-glycosaminoglycans (GAGs) le li-proteoglycans. Limolek'hule tsena li na le karolo ea bohlokoa lits'ebetsong tse fapaneng tsa baeloji, ho kenyeletsoa ho khomarela sele, ho thehoa ha matrix ea kantle ho sele le ho etsa lipontšo.