Tritylolmesartanethylester CAS:144690-33-5

Tritylolmesartanethylester e na le bohlokoa bo boholo ho khemistri ea meriana le ho sibolloa ha lithethefatsi, haholo-holo nts'etsopele ea li-receptor antagonists tsa angiotensin II tse nang le liprofayili tse ntlafalitsoeng tsa meriana. Jwalo ka se tswang ho meriana e tsebahalang ea antihypertensive olmesartan medoxomil, motsoako ona o sebetsa e le sethala sa bohlokoa bakeng sa ho kopanya le ho hlahloba li-analog tse ncha tse nang le katleho e ntlafetseng le thepa ea pharmacokinetic. Phuputsong ea meriana, Tritylolmesartanethylester e ithutoa ka bokhoni ba eona ba ho fetola sistimi ea renin-angiotensin, e bapalang karolo ea bohlokoa ho laoleng khatello ea mali, ho leka-lekana ha mokelikeli le ts'ebetso ea pelo le methapo ea mali. Ka ho batlisisa likamano tsa eona le li-receptor tsa angiotensin II, bafuputsi ba ikemiselitse ho rala metsoako e mecha e ka thibelang litlamorao tsa 'mele tsa angiotensin II ka katleho, e leng se lebisang nts'etsopele ea meriana ea antihypertensive ea moloko o latelang e nang le liphetho tse betere tsa kalafo le litla-morao tse fokotsehileng. Ho feta moo, liphetoho tsa sebopeho le litlhahlobo tsa meriana tsa Tritylolmesartanethylester le li-analog tsa eona li kenya letsoho kutloisisong ea likamano tsa sebopeho le ts'ebetso (SAR) ka har'a sehlopha sa li-receptor antagonist tsa angiotensin. Tsebo ena e tataisa moralo o utloahalang oa bakhethoa ba meriana e ntlafalitsoeng ba nang le kamano e ntlafetseng ea ho tlama li-receptor, khetho, le botsitso ba metabolism, e bula tsela bakeng sa tsoelo-pele kalafong ea mafu a pelo le methapo a kang khatello e phahameng ea mali, ho hloleha ha pelo, le nephropathy ea lefu la tsoekere. Ho feta moo, lits'ebetso tse ka bang teng tsa Tritylolmesartanethylester li atolohela lithutong tsa pele ho kliniki tse reretsoeng ho hlakisa liprofaele tsa eona tsa pharmacokinetic le pharmacodynamic, liprofaele tsa chefo, le bokhoni ba kalafo ka liteko tsa in vitro le in vivo. Lipatlisiso tsena li fana ka lintlha tsa bohlokoa bakeng sa ho lekola polokeho le katleho ea eona, qetellong li tšehetsa tsoelo-pele ea eona ho ea litekong tsa kliniki le nts'etsopele e ka bang teng ea meriana. Ka bokhutšoanyane, ts'ebeliso ea Tritylolmesartanethylester e kenyelletsa karolo ea eona ea bohlokoa k'hemistri ea meriana le lipatlisiso tsa meriana e le sethala sa moralo, ho kopanya le ho hlahloba li-anti-receptor tse ncha tsa angiotensin II, tse tlatsetsang nts'etsopele ea kalafo ea khatello e phahameng ea mali le pharmacology ea pelo le methapo.