Tofacitinib CAS:477600-75-2 Mofani oa Moetsi

Tofacitinib ke moriana o sebelisetsoang ho phekola ramatiki (RA), psoriasis, lefu la ho ruruha ha mala, le mafu a mang a sesole sa 'mele, hammoho le ho thibela ho haneloa ha ho kenngoa ha litho. Ke thibelo ea enzyme Janus kinase 3 (JAK3), e bolelang hore e sitisa tsela ea lipontšo ea JAK-STAT e fetisang tlhahisoleseling ka ntle ho sele ho ea khubung ea sele, e susumetsang phetolelo ea DNA. Haufinyane e bontšitsoe mohlaleng oa murine oa ramatiki e thehiloeng, tofacitinib e ntlafatsa lefu ka potlako ka ho thibela tlhahiso ea bathusi ba ho ruruha le ho hatella liphatsa tsa lefutso tse itšetlehileng ka STAT1 liseleng tsa manonyeletso. Katleho ena mohlaleng ona oa lefu e amana le thibelo ea litsela tsa lipontšo tsa JAK1 le 3, e leng se bontšang hore tofacitinib e ka fana ka melemo ea phekolo ka litsela tse sa amaneng le thibelo ea JAK3 feela.