Tofacitinib CAS:477600-75-2 Setšoantšo se hlahang ho moetsi oa thepa

Tofacitinib CAS:477600-75-2 Mofani oa Moetsi

Tofacitinib ke ea pele e nyenyane ea molek'hule kinase inhibitor e amohelehang bakeng sa phekolo ea RA.Tofacitinib ke inhibitor ea li-subtypes tse 'nè tsa Janus kinase (JAK): JAK1, JAK2, JAK3, le Tyk2.Tofacitinib e sebetsa ka ho thibela phosphorylation le ts'ebetso ea li-transducers tsa matšoao le li-activator tsa transcription (STATs), kahoo li thibela li-mediators tsa ho ruruha. manonyeletsong.

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Tofacitinib ke sethethefatsi bakeng sa ho phekola ramatiki ea ramatiki (RA), psoriasis, lefu la ho ruruha ha mala, le mafu a mang a immunology, hammoho le ho thibela ho hana ho fetisoa ha litho tsa 'mele.Ke inhibitor ea enzyme ea Janus kinase 3 (JAK3), e bolelang hore e kena-kenana le tsela ea pontšo ea JAK-STAT e fetisang boitsebiso ka ntle ho sele ka har'a nucleus ea sele, e susumetsang ho ngoloa ha DNA.Haufinyane tjena ho bontšitsoe ka mohlala oa murine oa ramatiki e thehiloeng, tofacitinib e ntlafalitse ka potlako lefu ka ho thibela tlhahiso ea bahlaseli ba ho ruruha le ho hatella liphatsa tsa lefutso tse itšetlehileng ka STAT1 ka lisele tse kopantsoeng. litsela, ho fana ka maikutlo a hore tofacitinib e ka fana ka molemo oa phekolo ka litsela tse sa amaneng le ho thibela JAK3 feela.

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Tlhahisoleseling e 'Ngoe:

Sebopeho	Setšoantšo sa C16H20N6O
Tlhahlobo	99%
Ponahalo	Phofo e tšoeu
Nomoro ea CAS.	477600-75-2
Ho paka	25KG
Shelf Life	lilemo tse 2
Polokelo	Boloka sebakeng se phodileng le se omileng
Setifikeiti	ISO.