CAS ea tert-butyl (2-chloropyridin-3-yl)carbamate:209798-48-1

Tert-butyl (2-chloropyridin-3-yl)carbamate e bapala karolo ea bohlokoa e le mokena-lipakeng oa metsoako e rarahaneng, e sebetsang ka lintho tse phelang e nang le lits'ebetso tse ka bang teng tsa meriana. Ho kenyelletsoa ha eona meralong ea limolek'hule ho nolofalletsa bafuputsi ho hlahloba bakhethoa ba meriana ba bacha ba shebaneng le libaka tsa kalafo tse kang mafu a methapo ea kutlo, mafu a tšoaetsanoang, kapa oncology. Boteng ba sehlopha sa chloropyridine bo fana ka reactivity e itseng le thepa ea pharmacophoric, e leng se etsang hore e be ea bohlokoa bakeng sa lipatlisiso tsa k'hemistri ea meriana. Ha ho sibolloa lithethefatsi, motsoako ona o ka sebetsa e le sebaka sa ho qala ho rala bakhethoa ba meriana ba ka bang teng, o sebelisa likarolo tsa oona tsa sebopeho ho fetola ts'ebetso ea baeloji le thepa ea pharmacokinetic. Ho feta moo, sehlopha sa tert-butyl se fana ka tšitiso ea steric, se susumetsa likamano tsa motsoako le lipheo tsa baeloji le ho kenya letsoho ho batlisiseng mekhoa e mecha ea phekolo. Ho feta moo, libakeng tsa thuto le tsa indasteri, bafuputsi ba ka sebelisa motheo ona ho lokisa lilaebrari tsa lintho tse fapaneng tse tsoang ho tsona bakeng sa lithuto tsa kamano ea sebopeho le mosebetsi, ho nolofalletsa ho tsebahatsa metsoako ea loto e nang le litlamorao tse lakatsehang tsa baeloji. Karolo ea eona ho kopanyeng lik'hemik'hale e atolohela tlhahisong ea li-intermediate tsa meriana le nts'etsopele ea mekhoa e mecha ea maiketsetso, e bonts'a thuso ea eona e pharaletseng mafapheng a saense. Ka kakaretso, carbamate ea tert-butyl (2-chloropyridin-3-yl) e bapala karolo ea bohlokoa ho phehelleng ho sibolloa ha meriana e mecha le lipatlisiso tsa lik'hemik'hale, e fana ka sethala sa nts'etsopele ea limolek'hule tse fapaneng tse sebetsang ka baeloji le metsoako e mahareng ea meriana.