S)-(+)-Camptothecin CAS:7689-03-4

(S) -(+)-Camptothecin e na le tshepiso kalafong ya mefuta e fapaneng ya kankere, haholo-holo lefapheng la chemotherapy. Mokgwa wa yona wa tshebetso o kenyeletsa ho shebana le ho thibela tshebetso ya topoisomerase I, e leng enzyme e hlokahalang bakeng sa ho lokolla DNA nakong ya karohano ya sele. Ka ho sitisa tshebetso ena, (S)-(+)-Camptothecin e thibela disele tsa kankere ho ikatisa le ho ata, qetellong e baka apoptosis kapa lefu la sele le hlophisitsweng. Motswako ona o bontshitse katleho kgahlanong le mefuta e mmalwa ya kankere, ho kenyeletswa kankere ya mala a matswele, ya mae a bomme le ya sele e nyane ya matshwafo, hara tse ding. Maiteko a dipatlisiso a shebane le ho ntshetsa pele di-derivatives le di-formulations tsa (S)-(+)-Camptothecin ho ntlafatsa ho qhibiliha ha yona le ho fumaneha ha yona, ho ntlafatsa thuso ya yona ya bongaka. Dithuto tsa bongaka le diteko di hlahlobile tshebediso ya (S)-(+)-Camptothecin e le moemedi a le mong kapa hammoho le di-agent tse ding tsa chemotherapy ho eketsa ditlamorao tsa yona tsa ho lwantsha hlahala ha e ntse e fokotsa dikarabelo tse mpe. Leha ho le jwalo, ho bohlokwa ho hlokomela hore (S)-(+)-Camptothecin e ka nna ya ba le chefo le ditlamorao tse mpe, e hlokang tlhokomelo le taolo e hlokolosi ke ditsebi tsa tlhokomelo ya bophelo. Phuputso ya (S)-(+)-Camptothecin le dihlahiswa tsa yona e ntse e tswela pele ho kganna kgatelopele kalafong ya kankere, e fana ka tshepo bakeng sa diphetho tse ntlafetseng tsa kalafo le boleng ba bophelo bakeng sa bakudi ba lwantshanang le mafu a fapaneng a kankere.