PhentolamineMesylate CAS:65-28-1

Phentolamine mesylate e phetha karolo e fapaneng ea bohlokoa lits'ebetsong tsa bongaka le lipatlisiso. E le vasodilator e matla le moemeli oa antihypertensive, e sebelisoa kalafong ea maemo a tšohanyetso a khatello ea mali, haholo-holo maemong a pheochromocytoma crisis, moo ho hlokahalang phokotso ea khatello ea mali kapele. E boetse e fumana thuso ho laoleng liketsahalo tsa khatello ea mali tse bakoang ke iatrogenic catecholamine nakong ea lits'ebetso tsa opereishene le mekhoa e meng ea bongaka. Ngakeng ea meno, phentolamine mesylate e sebelisoa e le moemeli oa ho khutlisa bohloko ba sebakeng seo, e thusang tsamaisong ea anesthesia ea lisele tse bonolo kamora lits'ebetso tsa meno tse kenyeletsang anesthetics ea sebakeng seo e nang le vasoconstrictor joalo ka epinephrine. Litlamorao tsa eona tsa vasodilator li thusa ho fokotsa thibelo ea phallo ea mali ea sebakeng seo le ho potlakisa ho hlaphoheloa ha phallo e tloaelehileng ea lisele. Ho feta moo, motsoako ona o sebelisoa lits'ebetsong tsa tlhahlobo tse kang thibelo le kalafo ea necrosis ea letlalo e bakoang ke ho ntšoa ha meriana e sebetsang ka vaso, ho netefatsa ho phalla ha lisele hantle. Ho feta moo, e ameha lithutong tsa lipatlisiso le litekong tsa kliniki tse hlahlobang ts'ebeliso ea eona e ka bang teng maemong a amanang le ho se lekane ha methapo ea mali, ho se sebetse hantle ha botona, le ketsahalo ea Raynaud, e kenyang letsoho tsoelo-peleng ea bongaka ba pelo le methapo ea mali. Karolo ea Phentolamine mesylate e atolohela libakeng tsa liteko e le sesebelisoa lipatlisisong tsa meriana le tsa 'mele, e thusa lipatlisisong tsa ts'ebetso ea adrenergic receptor, likarabo tsa methapo ea mali, le ho fetola ts'ebetso ea tsamaiso ea methapo ea kutlo. Bokhoni ba eona ba ho thibela li-receptor tsa adrenergic le ho susumetsa molumo oa methapo ea mali bo thusa kutloisisong ea fisioloji ea pelo le methapo ea mali le nts'etsopele ea mekhoa ea phekolo e shebaneng le litsela tsa matšoao a adrenergic. Ka kakaretso, lits'ebetso tse fapaneng tsa phentolamine mesylate li totobatsa bohlokoa ba eona meriana ea bongaka, bongaka ba meno, lipatlisiso le nts'etsopele ea meriana, e totobatsa bokhoni ba eona ba ho kenya letsoho tsamaisong e sebetsang ea maemo a pelo le methapo ea mali le nts'etsopele ea tsebo ea mahlale e amanang le ts'ebetso ea adrenergic receptor le taolo ea methapo ea mali.