Methyl1-Boc-3-pyrrolidinecarboxylate CAS:122684-33-7

Methyl 1-Boc-3-pyrrolidinecarboxylate e bonts'a lits'ebetso tse fapaneng ho tsoakong ea lintho tse phelang, lipatlisisong tsa meriana le saenseng ea lisebelisoa. E le karolo ea bohlokoa ea bohareng, e bapala karolo ea bohlokoa ho tsoakoeng ha meriana, li-analogue tsa lihlahisoa tsa tlhaho, le metsoako e sebetsang ka baeloji. Litšobotsi tsa eona tse ikhethang tsa sebopeho li etsa hore e be ea bohlokoa kahong ea li-scaffold tse rarahaneng tsa limolek'hule tse nang le mesebetsi e ka bang teng ea baeloji. K'hemistri ea meriana, motsoako ona o sebetsa e le selelekela sa bohlokoa bakeng sa ho tsoakoa ha bakhethoa ba meriana le metsoako e sebetsang ea meriana (API). Ho kenyelletsoa ha eona meralong ea limolek'hule ho thusa nts'etsopele ea li-agent tse ka bang teng tsa kalafo tse shebaneng le maemo a fapaneng a bongaka, ho kenyeletsoa le mathata a tsamaiso ea methapo ea bohareng, mafu a tšoaetsanoang le kankere. Ho feta moo, Methyl 1-Boc-3-pyrrolidinecarboxylate e fumana thuso libakeng tsa lipatlisiso tsa thuto le tsa indasteri, moo e sebelisoang ho batleng mekhoa e mecha ea maiketsetso, ho tsoakoa ho sa leka-lekaneng, le nts'etsopele ea likarabelo tse ncha tsa lik'hemik'hale. Ho arabela ha eona le ho lumellana ha eona le maano a fapaneng a maiketsetso ho tlatsetsa bohlokoa ba eona e le motheo oa kaho k'hemistri ea lintho tse phelang. Ho feta moo, motsoako ona o sebelisetsoa ho lokisa li-block tsa kaho tsa chiral le li-intermediate tse nang le lits'ebetso tlhahisong ea lik'hemik'hale tse ntle le lisebelisoa tse ikhethang. Karolo ea eona ho etseng metsoako e hloekileng ea enantiomeric e totobatsa bohlokoa ba eona tlhahisong ea limolek'hule tse rarahaneng tse hlokahalang bakeng sa meriana, lik'hemik'hale tsa temo le thepa e sebetsang. Ka kakaretso, lits'ebetso tse pharaletseng tsa Methyl 1-Boc-3-pyrrolidinecarboxylate li totobatsa bohlokoa ba eona e le sesebelisoa se feto-fetohang tlhahisong ea lintho tse phelang, nts'etsopele ea meriana le lipatlisiso tsa lik'hemik'hale, e leng se bontšang bohlokoa ba eona tlhahisong ea metsoako e mecha e nang le lits'ebetso tse fapaneng ho sibolloeng ha meriana, saense ea thepa le tlhahiso e ntle ea lik'hemik'hale.