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Leflunomide CAS: 75706-12-6 Mofani oa Moetsi

Leflunomide ke sethethefatsi se sebelisoang ka molomo se fetolang lefu la masapo 'me se ile sa qalisoa e le Arava US bakeng sa phekolo ea ramatiki ea lefuba (RA);ke sethethefatsi sa pele le se le seng feela se lokelang ho bontšoa ho fokotsa tšenyo ea lenonyeletso la RA, kahoo ho sebetsana le tlhoko ea bongaka e sa finyelloang.Leflunomide ke lithethefatsi tse sebetsang ka potlako le hoo e batlang e le metabolized ka ho feletseng (halofo ea bophelo, <60 metsotso) ho latela molomo. ho tsamaisoa ho teriflunomide, pharmacologically α-cyanoenol metabolite.


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Kopo le Phello

Leflunomide ha e sebetse, empa teriflunomide e thibela pyrimidine de novo synthesis ka tekanyo e tlaase ea phekolo ka ho thibela dihydroorotate dehydrogenase (enzyme e khethollang sekhahla bakeng sa motsoako oa UMP), e fokotsang DNA le RNA synthesis, le ho tšoara potoloho ea ho ata ha lisele le tlhahiso ea li-antibodies.Ho fokotseha ha dihydroorotate ho orotate ho etsahala ka nako e le 'ngoe le ho fokotseha ha cofactor ea eona, ubiquinone (coenzyme Q).Thibelo ea dihydroorotate dehydrogenase ka teriflunomide e bonts'a kinetics e se nang tlholisano le e se nang tlholisano.Tsamaiso ea leflunomide ho bakuli ba nang le ramatiki ea ramatiki e fella ka ho tlosoa ho tsoelang pele ha lisele tsa B le ho theola taolo ea tsamaiso ea 'mele ea ho itšireletsa mafung.

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Tlhahisoleseling e 'Ngoe:

Sebopeho C12H9F3N2O2
Tlhahlobo 99%
Ponahalo Phofo e tšoeu
Nomoro ea CAS. 75706-12-6
Ho paka 25KG
Shelf Life lilemo tse 2
Polokelo Boloka sebakeng se phodileng le se omileng
Setifikeiti ISO.

  • E fetileng:
  • E 'ngoe:

  • Ngola molaetsa wa hao mona mme o re romele wona