Glucose-6-Phosphate Dehydrogenase CAS:9001-40-5

Metabolism ea Lisele: G6PD e ameha tseleng ea metabolism ea glucose, haholo-holo tsela ea pentose phosphate. E susumetsa phetoho ea glucose-6-phosphate ho 6-phosphogluconolactone, e hlahisang NADPH ts'ebetsong. NADPH ke molek'hule ea bohlokoa bakeng sa lits'ebetso tse fapaneng tsa sele, ho kenyeletsoa ts'ireletso ea antioxidant, biosynthesis ea mafura a acid le k'holeseterole, le ho boloka botsitso ba redox ea sele.

Tšireletso ea Antioxidant: NADPH e hlahisoang ke G6PD e bohlokoa bakeng sa tlhahiso ea glutathione e fokotsehileng (GSH), molek'hule ea bohlokoa ea antioxidant. GSH e sireletsa lisele khatellong ea oxidative ka ho fokotsa li-free radical le mefuta ea oksijene e arabelang (ROS). Khaello ea G6PD e ka beha NADPH kotsing 'me ea fokotsa katleho ea ts'ireletso ea antioxidant, e leng se lebisang kotsing e eketsehileng ea tšenyo ea oxidative.

Hemolytic Anemia: Khaello ea G6PD ke khaello ea li-enzyme e atileng haholo lefatšeng ka bophara. E ama haholo banna 'me e ka lebisa ho haemolytic anemia, boemo bo khetholloang ke ho timetsoa ha lisele tse khubelu tsa mali. Lintho tse bakang mafu a itseng, joalo ka tšoaetso, meriana e itseng (mohlala, meriana ea malaria, lithethefatsi tsa sulfa), le lijo tse itseng (mohlala, linaoa tsa fava), li ka baka hemolysis ho batho ba nang le khaello ea G6PD. Khaello ena e baka ho hloleha ho laola khatello ea oxidative e hlahisoang ke lintho tsena tse bakang mafu, e leng se fellang ka ho senyeha ha lisele tse khubelu tsa mali.

Bongaka ba Meriana: Tlhahlobo ea G6PD e bohlokoa ho bongaka ba meriana ho thibela likarabelo tse mpe tsa meriana. Meriana e meng, joalo ka meriana e itseng ea malaria (mohlala, primaquine) le lithibela-mafu (mohlala, sulfonamides), e ka baka hemolysis ho batho ba nang le khaello ea G6PD. Tlhahlobo ea pele ea khaello ea G6PD e thusa ho khetholla batho ba kotsing 'me e ka tataisa khetho ea meriana kapa tšebeliso ea mekhoa e meng ea phekolo ho thibela liketsahalo tse matla tsa hemolytic.