Geldanamycin CAS: 30562-34-6

Leha geldanamycin e bontšitse ts'ebetso ea ho loantša kankere lithutong tsa laboratori, ts'ebeliso ea eona ea bongaka e lekanyelitsoe ka lebaka la liphephetso tse amanang le chefo le botsitso. Maiteko a lipatlisiso a ntse a tsoela pele ho nts'etsapele li-derivatives le li-analogues tsa geldanamycin tse nang le thepa e ntlafalitsoeng ea pharmacokinetic le litla-morao tse fokotsehileng bakeng sa lits'ebetso tse ka bang teng tsa kalafo. Libakeng tsa liteko, geldanamycin le li-derivatives tsa eona li 'nile tsa fuputsoa ka bokhoni ba tsona ba ho thibela ts'ebetso ea Hsp90, e leng se lebisang ho senyeha ha liprotheine tsa bareki tse amehang kholong ea lisele tsa mofetše le ho phela. Mokhoa ona o etsa hore geldanamycin e be mokhethoa ea tšepisang bakeng sa kalafo ea mofetše e reretsoeng, haholo-holo mofetšeng o itšetlehileng ka litsela tse laoloang ke Hsp90. Liteko tsa bongaka tse hlahlobang katleho le polokeho ea li-derivatives tsa geldanamycin ho bakuli ba mofetše li ntse li tsoela pele ho lekola bokhoni ba tsona e le li-agent tse loantšang mofetše. Lithuto tsena li ikemiselitse ho lekola melemo ea kalafo ea moriana, mekhoa e metle ea ho lekanya, sekhahla sa karabelo, le litlamorao life kapa life tse amanang le tsona ho fumana hore na li na le thuso efe ea bongaka ts'ebetsong ea oncology. Tšebelisano-'moho pakeng tsa bafuputsi, lik'hamphani tsa meriana, mekhatlo ea taolo le bafani ba tlhokomelo ea bophelo bo botle ke ea bohlokoa ho ntšetsa pele nts'etsopele ea mekhoa ea phekolo e thehiloeng ho geldanamycin le ho tlisa mekhoa e mecha ea phekolo e khahlanong le mofetše ho bakuli ba hlokang. Phuputso e tsoelang pele mabapi le boemo ba meriana le liphello tsa bongaka tsa li-derivatives tsa geldanamycin e na le tšepiso ea ho ntlafatsa maano le liphello tsa kalafo ea kankere nakong e tlang.