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2-Hydroxyisonicotinic acid CAS: 90-33-5
2-Hydroxysonicotinic acid ke motsoako oa isonicotinic acid, o khetholloang ke boteng ba sehlopha sa hydroxyl sebakeng sa bobeli sa lesale la pyridine. Motsoako ona o bonts'a mesebetsi e fapaneng ea baeloji, ho kenyeletsoa le thepa e ka bang teng ea antibacterial le anti-inflammatory. Ho tšoana ha sebopeho sa oona le metsoako e meng ea nicotinic acid ho etsa hore e be sepheo se khahlisang bakeng sa nts'etsopele ea meriana. Bafuputsi ba 'nile ba hlahloba ts'ebeliso ea oona k'hemistri ea meriana, haholo-holo kalafong ea mafu a fapaneng. Motsoako ona o sebetsa e le motheo oa ho etsa limolek'hule tse rarahaneng haholoanyane 'me o hapile tlhokomelo masimong a tlhahiso ea lintho tse phelang le lipatlisiso tsa meriana.
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Methyl 2-aminopyridine-4-carboxylate CAS: 6937-03-7
Methyl 2-aminopyridine-4-carboxylate ke motsoako o tsoang ho pyridine o nang le sehlopha sa amino sebakeng sa 2 le ester ea carboxylate sebakeng sa 4, ka sehlopha sa methyl se hoketsoeng ho asiti ea carboxylic. Motsoako ona o na le thahasello k'hemistring ea meriana ka lebaka la mesebetsi ea oona e ka bang teng ea baeloji, ho kenyeletsoa le thepa ea ho loantša likokoana-hloko le ho thibela ho ruruha. Tlhophiso e ikhethang ea lihlopha tse sebetsang e ntlafatsa ts'ebetso ea eona le thuso ea eona e le motheo o feto-fetohang oa ho kopanya lintho tse phelang. Lipatlisiso li ntse li tsoela pele ho hlahloba lits'ebetso tsa eona nts'etsopele ea lithethefatsi le masimo a mang, li bontša bohlokoa ba eona sebakeng sa k'hemistri ea heterocyclic.
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Tofacitinib Citrate CAS:540737-29-9
Tofacitinib citrate ke thibelo ea Janus kinase (JAK) e nooang e sebelisetsoang haholo-holo kalafo ea ramatiki, ramatiki ea psoriatic, le colitis ea ulcerative. E sebetsa ka ho thibela li-enzyme tsa JAK1 le JAK3 ka mokhoa o ikhethileng, tse bapalang karolo ea bohlokoa litseleng tsa lipontšo tsa li-cytokine tse fapaneng tse amehang lits'ebetsong tsa ho ruruha. Ka foromo ea limolek'hule ea C16H20N6O5S·C6H8O7, tofacitinib citrate e bontšitse katleho ea ho fokotsa ho ruruha le ho ntlafatsa boleng ba bophelo ba mokuli. E amohetsoe bakeng sa ts'ebeliso ea bongaka linaheng tse 'maloa, lipatlisiso tse tsoelang pele li ikemiselitse ho hlahloba lits'ebetso tsa eona tse pharaletseng tsa kalafo, boemo ba polokeho, le liphetho tsa nako e telele mafung a fapaneng a autoimmune.
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CAS ea Cyclen: 294-90-6
Cyclen, kapa 1,4,7,10-tetraazacyclododecane, ke motsoako oa polyamine o tsebahalang ka sebopeho sa oona se ikhethang sa potoloho se nang le liathomo tse 'ne tsa naetrojene tse kentsoeng lesale la litho tse leshome le metso e 'meli. Ka foromo ea molek'hule ea C8H16N4, cyclen e sebetsa e le ligand ea bohlokoa k'hemistring ea tšebelisano ka lebaka la bokhoni ba eona ba ho theha metsoako e tsitsitseng ka litšepe tsa phetoho. Thepa ea eona ea chelating e etsa hore e be ea bohlokoa lits'ebetsong tse fapaneng, ho kenyeletsoa k'hemistri ea meriana, meriana ea radiopharmaceuticals, le k'hemistri ea supramolecular. Phuputso e tsoelang pele e hlahloba bokhoni ba cyclen lits'ebetsong tsa ho fana ka meriana le nts'etsopele ea li-agent tse shebaneng le litšoantšo, e totobatsa bohlokoa ba eona mahlaleng a motheo le a sebelisoang.
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![4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane CAS:57280-22-5](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT317.png)
4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane CAS:57280-22-5
4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane ke motsoako oa lintho tse phelang oa bicyclic o khetholloang ka sebopeho sa oona se ikhethang se nang le likhokahano tse peli tsa ether le liathomo tse tharo tsa oksijene ka har'a moralo oa bicyclic. Ka foromo ea limolek'hule C10H16O3, motsoako ona o bontša litšobotsi tse khahlisang tsa lik'hemik'hale ka lebaka la boteng ba lihlopha tsa methyl le mesebetsi ea ether. Moralo oa eona oa bicyclic o tlatsetsa botsitsong le ho sebetsa ha oona hape, e leng se etsang hore e be mokhethoa ea ka bang teng bakeng sa lits'ebetso tse fapaneng k'hemistring ea lintho tse phelang ea maiketsetso. Lipatlisiso li hlahloba tšebeliso ea oona ho kopanyeng limolek'hule tse rarahaneng haholoanyane le bokhoni ba oona e le motheo oa kaho saenseng ea meriana le thepa.
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![4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine CAS:479633-63-1](https://cdn.globalso.com/xindaobiotech/VMLV8UWXAZ0XBLS6M290.png)
4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine CAS:479633-63-1
4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine ke motsoako oa maiketsetso o tsebahalang ka lits'ebeliso tsa oona tse ka bang teng tsa meriana. E na le sebopeho se ikhethang se kenyelletsang motheo oa pyrrolopyrimidine, sebaka sa chloro, le karolo ea sulfonyl e hokahaneng le sehlopha sa para-methylphenyl. Sebopeho sena sa sebopeho se ka kenya letsoho ts'ebetsong ea sona ea baeloji, e leng se etsang hore e be mokhethoa oa lipatlisiso libakeng tse kang oncology kapa ho ruruha. Lithuto li ntse li tsoela pele ho hlahloba mekhoa ea eona ea ts'ebetso, katleho le boemo ba polokeho, ka sepheo sa ho khetholla ts'ebeliso ea eona e ka bang teng ea kalafo maemong a fapaneng a bongaka.
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3-Pyridinesulfonyl chloride CAS:16133-25-8
3-Pyridinesulfonyl chloride ke motsoako oa bohlokoa oa lintho tse phelang o nang le foromo ea limolek'hule C6H6ClN O2S. Ke derivative ea sulfonyl chloride ea pyridine, e nang le sehlopha se sebetsang sa sulfonyl chloride se hoketsoeng boemong ba boraro ba lesale la pyridine. Motsoako ona o sebelisoa haholo-holo tlhahisong ea lintho tse phelang e le reagent bakeng sa ho kenyelletsa lihlopha tsa sulfonyl ka har'a li-substrate tse fapaneng. Ho arabela ha oona ho o lumella ho nka karolo liketsong tsa ho nkeloa sebaka ha nucleophilic, e leng se etsang hore e be ea bohlokoa ho kopanyeng li-sulfonamides le limolek'hule tse ling tse sebetsang. Ho feta moo, 3-pyridinesulfonyl chloride e na le lits'ebetso tse ka bang teng meriana le lik'hemik'hale tsa temo.
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2-Aminoisonicotinic acid CAS: 13362-28-2
2-Aminoisonicotinic acid ke motsoako oa pyridine, haholo-holo isomer ea nicotinic acid, e khetholloang ke boteng ba sehlopha sa amino sebakeng sa 2 sa sebopeho sa isonicotinic acid. Ka foromo ea molek'hule ea C6H6N2O2, motsoako ona o bontša litšobotsi tse khahlisang tsa lik'hemik'hale 'me o hapile tlhokomelo k'hemistring ea meriana bakeng sa mesebetsi ea eona e ka bang teng ea baeloji, ho kenyeletsoa le litlamorao tsa antimicrobial le anti-inflammatory. Mesebetsi ea amino le carboxylic acid e nolofalletsa liphetoho tse fapaneng tsa lik'hemik'hale, e leng se etsang hore e be sebaka sa bohlokoa sa ho kopanya lintho tse phelang. Lipatlisiso tse tsoelang pele li hlahloba bokhoni ba eona ba kalafo, li totobatsa bohlokoa ba eona nts'etsopele ea meriana le lits'ebetsong tse ling.
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2-Amino-4-cyanopyridine CAS:42182-27-4
2-Amino-4-cyanopyridine ke motsoako oa pyridine o khetholloang ke sehlopha sa amino se boemong ba 2 le sehlopha sa cyano se boemong ba 4 ba lesale la pyridine. Ka foromo ea molek'hule ea C6H4N4, motsoako ona o bontša thepa e khahlang ea lik'hemik'hale le mesebetsi e ka bang teng ea baeloji. E ithutiloe bakeng sa ts'ebeliso ea eona k'hemistring ea meriana, haholo-holo nts'etsopele ea lithethefatsi ka lebaka la litlamorao tsa eona tse ka bang teng tsa ho loantša likokoana-hloko, ho bolaea likokoana-hloko le ho thibela ho ruruha. Boteng ba lihlopha tsena ka bobeli bo ntlafatsa ts'ebetso ea eona, e leng se etsang hore e be sebaka sa bohlokoa sa ho kopanya lintho tse phelang. Lipatlisiso li ntse li tsoela pele ho hlahloba ho tenyetseha ha eona mafapheng a fapaneng ho kenyeletsoa meriana le lik'hemik'hale tsa temo.
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2-(4-Hydroxyphenyl)-4-methyl-5-thiazolecarboxylic acid, ethyl ester, hydrochloride (1:1) CAS:399017-10-8
2-(4-Hydroxyphenyl)-4-methyl-5-thiazolecarboxylic acid, ethyl ester, hydrochloride (1:1) ke motsoako oa thiazole, o khetholloang ka sebopeho sa oona se ikhethang se kenyeletsang sehlopha sa hydroxyl, sehlopha sa methyl, le ethyl ester. Motsoako ona o hapile thahasello k'hemistring ea meriana ka lebaka la mesebetsi ea oona e ka bang teng ea baeloji, joalo ka thepa ea ho thibela ho ruruha le ea ho loantša likokoana-hloko. Sebopeho sa letsoai la hydrochloride se ntlafatsa ho qhibiliha le botsitso, se nolofalletsa tšebeliso ea lona mefuteng ea meriana. Lipatlisiso li ntse li tsoela pele ho batlisisa katleho ea eona lits'ebetsong tse fapaneng tsa phekolo, e leng se etsang hore e be mokhethoa oa bohlokoa bakeng sa lithuto tse ling tsa nts'etsopele ea meriana le ntlafatso ea loto.
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3-Methyl-4-nitropyridine N-Oxide CAS:1074-98-2
3-Methyl-4-nitropyridine N-oxide ke motsoako oa pyridine o khetholloang ke sehlopha sa methyl sebakeng sa 3 le sehlopha sa nitro sebakeng sa 4 sa lesale la pyridine, hammoho le sehlopha se sebetsang sa N-oxide. Motsoako ona o bonts'a litšobotsi tse hlahelletseng tsa lik'hemik'hale le mesebetsi ea baeloji, e leng se etsang hore o be le thahasello masimong a fapaneng a kang k'hemistri ea meriana le lik'hemik'hale tsa temo. Boteng ba lihlopha tsa nitro le N-oxide ka bobeli bo ka ntlafatsa ts'ebetso ea eona le lits'ebetso tse ka bang teng k'hemistring ea maiketsetso. Lipatlisiso li ntse li tsoela pele ho hlahloba thuso ea motsoako ho sibolloeng ha lithethefatsi le lits'ebetsong tse ling, li bontša bohlokoa ba oona k'hemistring ea lintho tse phelang ea mehleng ena.
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(1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine CAS:511534-44-4
(1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine ke motsoako oa bohlokoa oa chiral o nang le sehlopha se sebetsang sa sulfonamide le mokokotlo oa diphenylethylene. Ka foromo ea limolek'hule ea C16H20N2O2S, motsoako ona o bapala karolo ea bohlokoa ho etseng le ho etseng catalysis ka lebaka la bokhoni ba oona ba ho theha libaka tse tsitsitseng tsa chiral. Sebopeho sa oona se ikhethang se lumella liketso tse khethiloeng, e leng se etsang hore e be ea bohlokoa ntlafatsong ea meriana le lik'hemik'hale tsa temo. Lipatlisiso tse tsoelang pele li hlahloba lits'ebetso tsa oona ho etseng stereoselective, li totobatsa bokhoni ba eona e le ligand k'hemistri ea organometallic le ho atolosa bohlokoa ba eona ho etseng lintho tsa tlhaho tsa sejoale-joale.
