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Lasmiditant CAS:439239-90-4
Lasmiditan, e rekisoang tlasa lebitso la Reyvow, ke motsoako o mocha oa meriana o etselitsoeng ho fokotsa litlhaselo tse matla tsa migraine ho batho ba baholo. Ke oa sehlopha sa li-agonists tse khethiloeng tsa serotonin receptor, tse shebaneng haholo le mofuta oa 5-HT1F receptor. Mokhoa ona oa ts'ebetso o khetholla Lasmiditan ho mekhoa ea setso ea migraine, kaha ha e bake ho ruruha ha methapo ea mali, e leng se etsang hore e lokele bakuli ba nang le mabaka a kotsi a pelo le methapo ea mali.
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N-Methylcarbonyl-2-chloroacetamidrazone CAS:155742-64-6
N-Methylcarbonyl-2-chloroacetamidrazone ke motsoako oa lik'hemik'hale o tsejoang ka ts'ebeliso ea oona e mengata ho tsoakoeng ha lintho tse phelang le k'hemistri ea ho hokahanya. Ho kopanya ha eona ho kenyelletsa karabelo ea N-methylcarbamoyl chloride le 2-chloroacetohydrazide, e leng se fellang ka motsoako o nang le thepa e ikhethang ea sebopeho le ts'ebetso. Motsoako ona o khetholloa ka bokhoni ba oona ba ho theha metsoako e nang le li-ion tse fapaneng tsa tšepe, e leng se etsang hore e be ea bohlokoa lithutong tsa k'hemistri ea ho hokahanya. Ho feta moo, lihlopha tsa eona tsa carbonyl le amidrazone li kenya letsoho ho reactivation ea eona le mesebetsing e ka bang teng ea meriana, e leng libaka tse tsoelang pele ho thahasello ea lipatlisiso.
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Lasmiditan HCl CAS:613677-28-4
Lasmiditan hydrochloride (Lasmiditan HCl) ke motsoako oa meriana o tsebahalang ka karolo ea oona ea ho phekola litlhaselo tse matla tsa migraine ho batho ba baholo. E ntlafalitsoe e le agonist ea serotonin receptor e khethiloeng, e shebaneng haholo le mofuta oa 5-HT1F receptor, Lasmiditan HCl e emela tsoelo-pele e kholo kalafong ea migraine ka lebaka la mokhoa oa eona o ikhethang oa ts'ebetso le katleho ea kliniki.
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(6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone CAS:613678-03-8
(6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone, e tsejoang hape e le aminopyridine methylpiperidone, ke motsoako oa lik'hemik'hale o nang le litlamorao tse kholo k'hemistring ea meriana le lipatlisisong tsa meriana. E kopantsoe ka karabelo ea 6-aminopicolinic acid le 1-methylpiperidin-4-one, motsoako ona o bonts'a likarolo tse ikhethang tsa sebopeho tse tlatsetsang bokhoni ba oona ba meriana le ho tenyetseha ha ts'ebetso.
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(S)-(+)-3-Quinuclidinol CAS:34583-34-1
(S)-(+)-3-Quinuclidinol, e tsejoang hape e le quinuclidinol, ke motsoako oa bohlokoa k'hemistring ea lintho tse phelang le lipatlisisong tsa meriana ka lebaka la ho ikhetha ha eona ka sebopeho le ts'ebeliso e mengata. Motsoako ona oa chiral o nkiloe ho quinuclidine 'me o bontša thepa e ikhethang ea lik'hemik'hale le ea meriana e hohetseng tlhokomelo mafapheng a fapaneng a saense.
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APEREPITANT INTERMEDIATES CAS:171482-05-6
Li-intermediate tsa Aprepitant li bapala karolo ea bohlokoa tlhahisong ea meriana ea aprepitant, e leng mohanyetsi ea matla oa neurokinin-1 (NK1) receptor o sebelisoang haholo-holo ho thibeleng ho nyekeloa ke pelo le ho hlatsa ho bakoang ke chemotherapy (CINV). Li-intermediate tsena ke likarolo tsa bohlokoa tseleng ea maiketsetso ea mehato e mengata e lebisang tlhahisong ea ho qetela ea aprepitant. Aprepitant ka boeona e tsejoa ka katleho ea eona ho laoleng CINV, e fana ka phomolo e kholo ho bakuli ba tšoaroang ke chemotherapy. Ho kopanngoa ha aprepitant ho kenyelletsa mehato e 'maloa ea bohlokoa, ka li-intermediate tse sebetsang e le li-block tse hahang tse nolofalletsang tlhahiso e sebetsang ea moemeli enoa oa bohlokoa oa phekolo.
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2,4,6-TRIFLUOROBENZOYL CHLORIDE CAS:79538-29-7
2,4,6-Trifluorobenzoyl chloride, e tsejoang hape e le trifluorobenzoyl chloride, ke motsoako oa bohlokoa oa lik'hemik'hale o bohlokoa bakeng sa ts'ebeliso ea oona e feto-fetohang ho etseng lintho tse phelang le lits'ebetsong tsa indasteri. Ka lebaka la chlorination ea 2,4,6-trifluorobenzoic acid, motsoako ona o na le litšobotsi tse ikhethang tsa lik'hemik'hale tse tlatsetsang ts'ebelisong ea oona e pharaletseng masimong a fapaneng.
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4-Chloro-6-iodoquinazoline CAS:98556-31-1
4-Chloro-6-iodoquinazoline ke motsoako oa lik'hemik'hale o nang le foromo ea limolek'hule C9H5ClIN2. E khetholloa ka boteng ba liathomo tsa chlorine le iodine tse hoketsoeng sebopehong sa lesale la quinazoline. Motsoako ona o sebelisoa haholo-holo lipatlisisong tsa meriana le tlhahiso ea lintho tse phelang ka lebaka la ts'ebeliso ea oona e ka bang teng ho nts'etsapele meriana e mecha le limolek'hule tse ling tse sebetsang ka baeloji.
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(R)-3-Quinuclinol CAS:25333-42-0
(R)-3-Quinuclinol, e tsejoang hape e le quinuclidinol, ke motsoako oa bohlokoa k'hemistring ea lintho tse phelang le lipatlisisong tsa meriana ka lebaka la ho ikhetha ha eona ka sebopeho le ts'ebeliso e mengata. Motsoako ona oa chiral o nkiloe ho quinuclidine 'me o bontša thepa e ikhethang ea lik'hemik'hale le ea meriana e hohetseng tlhokomelo mafapheng a fapaneng a saense.
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![(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate CAS:200000-59-5](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT235.png)
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate CAS:200000-59-5
Motsoako (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate ke molek'hule e rarahaneng ea lintho tse phelang e nang le litšobotsi tse itseng tsa sebopeho le tsa meriana. Ke oa sehlopha sa metsoako ea morpholine, e atisang ho sebelisoa k'hemistri ea meriana ka lebaka la mesebetsi ea eona e fapaneng ea baeloji.
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![(S)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine CAS:608141-42-0](https://cdn.globalso.com/xindaobiotech/1ZNB2ZF342ZWRNG304.png)
(S)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine CAS:608141-42-0
(S)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine ke motsoako oa lik'hemik'hale o tsejoang ka ts'ebeliso ea oona e mengata ho tsoakoeng ha lintho tse phelang le k'hemistri ea meriana. E entsoe ka karabelo ea (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone ka ammonia kapa amine, motsoako ona o na le likarolo tse ikhethang tsa sebopeho tse tlatsetsang ho mefuta-futa ea oona ea ts'ebetso le mesebetsi e ka bang teng ea meriana.
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(R)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine CAS:608142-27-4
(R)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine ke motsoako wa dikhemikhale o tsebahalang ka tshebediso ya wona e fapaneng ho etseng dintho tse phelang le k'hemistri ya meriana. Ka lebaka la karabelo ya 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone e nang le ammonia kapa amine, motsoako ona o bontsha dikarolo tse ikgethang tsa sebopeho tse tlatsetsang ho tenyetseheng ha wona mosebetsing le mesebetsing e ka bang teng ya dikhemikhale.
