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Adenosine CAS: 58-61-7
Adenosine ke nucleoside e entsoeng ka adenine le ribose, e bapala karolo ea bohlokoa metabolism ea sele. E sebetsa e le motheo oa motheo oa adenosine triphosphate (ATP), chelete ea mantlha ea matla litsamaisong tsa baeloji. Ntle le mesebetsi ea eona e amanang le matla, adenosine e ameha lits'ebetsong tse fapaneng tsa 'mele, ho kenyeletsoa phetisetso ea methapo ea kutlo, ho ruruha ha methapo ea mali, le taolo ea potoloho ea boroko le ho tsoha. E sebetsa ho li-receptor tse itseng, e susumetsa sekhahla sa pelo le phallo ea mali. Ka bongaka, adenosine e sebelisoa meriana, haholo-holo kalafong ea li-arrhythmia tse itseng tsa pelo. Mesebetsi ea eona e mengata e totobatsa bohlokoa ba adenosine bophelong bo botle le bokuling.
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Uridine 5-monophosphate, letsoai la disodium CAS:3387-36-8
Uridine 5-monophosphate, letsoai la disodium (UMP) ke nucleotide e bapalang karolo ea bohlokoa metabolism ea sele le tlhahiso ea RNA. E kenyelletsa pyrimidine base uracil, tsoekere ea ribose, le sehlopha sa phosphate, UMP e bohlokoa bakeng sa lits'ebetso tse fapaneng tsa baeloji, ho kenyeletsoa ho thehoa ha li-nucleic acid le taolo ea litsela tsa metabolism. Sebopeho sa letsoai la disodium se ntlafatsa ho qhibiliha ha lona le botsitso litharollong tsa metsi, e leng se etsang hore e lokele lipatlisiso tsa laboratori le lits'ebetsong tsa kalafo. UMP e hapile tlhokomelo ka lebaka la thepa ea eona e ka bang teng ea tšireletso ea methapo le ho ntlafatsa tsebo, hammoho le karolo ea eona ho ntlafatseng bophelo bo botle ba sele ka kakaretso.
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Cytidine 5′-(disodium phosphate) CAS:6757-06-8
Cytidine 5′- (disodium phosphate) ke motsoako oa nucleotide o entsoeng ka cytosine ea motheo oa pyrimidine, tsoekere ea ribose, le sehlopha sa phosphate. Motsoako ona o bapala karolo ea bohlokoa lits'ebetsong tse fapaneng tsa biochemical, ho kenyeletsoa le tlhahiso ea RNA, litsela tsa taolo, le lipontšo tsa sele. Sebopeho sa letsoai la disodium se ntlafatsa ho qhibiliha ha lona le botsitso maemong a 'mele, e leng se etsang hore le lokele lipatlisiso tsa laboratori le lits'ebetso tse ka bang teng tsa kalafo. Cytidine 5′- (disodium phosphate) e hapile thahasello ea ho kenella ha eona metabolism ea nucleic acid le melemo ea eona e ka bang teng ho ntlafatseng ts'ebetso ea kelello le ho tšehetsa bophelo bo botle ba sele.
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5-Azacytidine CAS:320-67-2
5-Azacytidine ke cytidine e entsoeng ka nucleoside e tšoanang le e entsoeng ka cytidine e nang le athomo ea naetrojene sebakeng sa 5 sa lesale la pyrimidine, e nkang sebaka sa athomo ea carbon. Phetoho ena e fana ka thepa e ikhethang ea meriana, e etsang hore e be motsoako oa bohlokoa baelojing ea limolek'hule le kalafo ea kankere. Jwalo ka mothibi ea matla oa DNA methyltransferase, 5-azacytidine e ka tsosolosa liphatsa tsa lefutso tse khutsitseng ka ho fetola mekhoa ea methylation ea DNA, ka hona e susumetsa tlhahiso ea liphatsa tsa lefutso. Qalong e qapiloe bakeng sa ho phekola mofetše oa mali, 5-azacytidine e hapile tlhokomelo bakeng sa ts'ebeliso ea eona e ka bang teng kalafong ea epigenetic, meriana ea ho tsosolosa, le lipatlisiso tse shebaneng le mafu a fapaneng a khetholloang ke taolo e sa tloaelehang ea liphatsa tsa lefutso.
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2′-Fluoro-2′-deoxyuridine CAS:784-71-4
2′-Fluoro-2′-deoxyuridine (FdU) ke analoge ea nucleoside ea deoxyuridine, moo athomo ea haedrojene e boemong ba 2′ ba tsoekere ea ribose e nkeloang sebaka ke athomo ea fluorine. Phetoho ena e ntlafatsa botsitso le ts'ebetso ea bioloji ea motsoako, e leng se etsang hore e be ea bohlokoa lipatlisisong tsa biochemical le lits'ebetsong tsa kalafo. FdU e tsebahala haholo ka karolo ea eona e le moemeli oa antiviral le anticancer, kaha e ka sitisa tlhahiso ea DNA le ho thibela ho ikatisa ha livaerase tse itseng le lisele tsa kankere. Thepa ea eona e ikhethang e etsa hore e be sesebelisoa sa bohlokoa nts'etsopele ea mekhoa ea phekolo e reretsoeng le lithuto tsa baeloji ea limolek'hule.
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![4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT260.png)
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one ke analoge e rarahaneng ea nucleoside e nang le motheo oa pyrimidine o hoketsoeng tsoekere e fetotsoeng ea ribose. Boteng ba athomo ea fluorine le lihlopha tsa hydroxyl sebopehong sa eona bo ntlafatsa thepa ea eona ea biochemical, e leng se etsang hore e be mokhethoa ea khahlisang bakeng sa lipatlisiso tsa antiviral le anticancer. Motsoako ona o na le lits'ebeliso tse ka bang teng k'hemistri ea meriana, haholo-holo e le moemeli oa phekolo o shebaneng le ho hlophisoa ha nucleic acid le litsela tsa metabolism linthong tse phelang tse bakang mafu. Litšobotsi tsa eona tse ikhethang tsa sebopeho li lumella tšebelisano e ntle le lipheo tsa baeloji tse amehang metabolism ea DNA le RNA.
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1,3,5-tri-O-benzoyl-alpha-D-ribofuranose CAS:22224-41-5
1,3,5-Tri-O-benzoyl-alpha-D-ribofuranose ke mofuta oa ribose o fetotsoeng ka lik'hemik'hale, o nang le lihlopha tse tharo tsa benzoyloxy tse hoketsoeng maemong a 1, 3, le 5 a sebopeho sa ribofuranose. Phetoho ena e ntlafatsa ho qhibiliha ha eona le botsitso, e leng se etsang hore e be molemo lits'ebetsong tse fapaneng tsa maiketsetso k'hemistring ea lintho tse phelang le k'hemistri ea biochemistry. Jwalo ka se sirelelitsoeng sa ribose, e sebetsa e le mokena-lipakeng oa ho kopanya li-nucleoside le li-nucleotide, likarolo tsa bohlokoa tsa RNA le DNA. Thepa ea eona e ikhethang e etsa hore 1,3,5-tri-O-benzoyl-alpha-D-ribofuranose e be ea bohlokoa bakeng sa bafuputsi ba batlang ho nts'etsapele li-agent tse ncha tsa kalafo le thepa k'hemistring ea nucleotide.
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2′-O-methyluridine CAS:2140-76-3
2′-O-Methyluridine ke nucleoside e hlahang ka tlhaho moo sehlopha sa methyl se hokahaneng le athomo ea oksijene ea boemo ba 2′ ba tsoekere ea ribose ho uridine. Phetoho ena e ntlafatsa botsitso le ts'ebetso ea limolek'hule tsa RNA, e leng se etsang hore e be karolo ea bohlokoa lits'ebetsong tse fapaneng tsa baeloji. 2′-O-Methyluridine e bapala karolo ea bohlokoa sebopehong le ts'ebetsong ea li-ribonucleic acid (RNAs), ho kenyeletsoa le messenger RNA (mRNA) le transfer RNA (tRNA). Boteng ba eona bo ka ama botsitso ba RNA, katleho ea phetolelo, le likamano le liprotheine le li-nucleic acid tse ling, e leng se etsang hore e be karolo ea bohlokoa thutong ea baeloji ea limolek'hule le lits'ebetsong tsa kalafo.
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adenosine 5′-monophosphate sodium* ho tsoa tomosong CAS:4578-31-8
Adenosine 5′-monophosphate sodium (AMP) ke nucleotide e nkiloeng ho adenosine e bapalang karolo ea bohlokoa metabolism ea sele. AMP e bohlokoa bakeng sa lits'ebetso tse fapaneng tsa baeloji, ho kenyeletsoa phetiso ea matla, phetisetso ea lets'oao, le joalo ka selelekela sa tlhahiso ea ATP le li-nucleotide tse ling. Mofuta oa letsoai la sodium oa AMP o ka fumanoa ho tomoso, e nang le li-nucleotide tse ngata ka lebaka la litsela tsa eona tse sebetsang tsa metabolism. Motsoako ona o sebelisoa hangata ho biochemistry le pharmacology e le reagent ea biochemical, tlatsetso ea lijo, le tlatsetso ea lijo, ka lebaka la melemo ea eona ea bophelo bo botle le ts'ebeliso ea eona ho ntšetseng pele metabolism ea matla.
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2′-Deoxycytidine CAS:951-77-9
2′-Deoxycytidine ke nucleoside e entsoeng ka tsoekere ea deoxyribose le cytosine, e khetholloang ke ho ba sieo ha sehlopha sa hydroxyl boemong ba 2′ ba ribose. Phetoho ena e e etsa karolo ea bohlokoa ea DNA, moo e kopanang le guanine nakong ea ho kopanya motheo. 2′-Deoxycytidine e bapala karolo ea bohlokoa metabolism ea sele le tlhahiso ea DNA, e sebeletsa e le motheo oa deoxycytidine triphosphate (dCTP), e leng ea bohlokoa bakeng sa ho ikatisa le ho lokisa DNA. Ho feta moo, nucleoside ena e na le litlamorao tsa bohlokoa lipatlisisong tsa baeloji ea limolek'hule, kalafo ea kankere, le maano a antiviral, e totobatsang bohlokoa ba eona lipatlisisong tsa motheo le lits'ebetsong tsa kliniki.
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2,2′-cyclouridine CAS:3736-77-4
2,2′-Cyclouridine ke motsoako oa bicyclic nucleoside oa uridine, o khetholloang ka ho thehoa ha sebopeho se ikhethang sa potoloho se kenyeletsang maemo a 2′ le 2” a karolo ea ribose. Phetoho ena ea sebopeho e fana ka litšobotsi tse ikhethang tsa biochemical tse susumetsang botsitso ba eona le ts'ebetso ea baeloji. 2,2′-Cyclouridine e hapile thahasello baelojing ea lik'hemik'hale le k'hemistri ea meriana ka lebaka la ts'ebeliso ea eona e ka bang teng e le moemeli oa antiviral le lipatlisisong tsa RNA. Bokhoni ba eona ba ho fetola likamano tsa nucleic acid bo e etsa sesebelisoa sa bohlokoa sa ho ithuta likamano tsa sebopeho sa RNA le ts'ebetso, e leng se ka lebisang tsoelo-peleng ea maano a kalafo a shebaneng le tšoaetso ea vaerase le mafu a liphatsa tsa lefutso.
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2-Aminoadenosine CAS:2096-10-8
2-Aminoadenosine ke ntho e hlahang ka tlhaho ho adenosine e tswang ho nucleoside, e khetholloang ke boteng ba sehlopha sa amino sebakeng sa 2 sa tsoekere ya ribose. Phetoho ena e fetola haholo thepa le mesebetsi ya yona ya biochemical, e e etsang molek'hule ya bohlokwa ditsamaisong tse fapaneng tsa fisioloji. 2-Aminoadenosine e ameha ho tsamaiseng matshwao a sele, metabolism, le ditseleng tsa taolo, ho kenyeletswa le tse amanang le homeostasis ya matla le phetisetso ya methapo ya kutlo. Ditshebediso tsa yona tse ka bang teng tsa kalafo di akaretsa masimo a mangata, ho kenyeletswa neurobiology le cardiology, moo e ka susumetsang dikarabelo tsa sele kgatellong ya maikutlo le kotsi. Ha dipatlisiso di ntse di tswela pele, 2-aminoadenosine e na le tshepiso ya ho ntshetsa pele metswako e metjha ya bioactive le di-agent tsa kalafo.
