ETHYL 2-METHYL-4,4,4-TRIFLUOROACETOACETATE CAS:344-00-3

N-Ethyl 2-methyl-4,4,4-trifluoroacetoacetate (EMTFA) e khetholloa ka sebopeho sa eona sa limolek'hule, se kenyeletsang sehlopha sa trifluoromethyl (-CF3) se hoketsoeng mokokotlong oa β-keto ester. Sebopeho sena se fana ka botsitso bo boholo le karabelo ho EMTFA, e leng se etsang hore e lokele mefuta e mengata ea lits'ebetso tsa lik'hemik'hale. Hangata EMTFA e teng e le mokelikeli o hlakileng, o se nang 'mala o nang le ntlha e belang e ka bang 140°C mme e bontša ho qhibiliha ho hotle litharollong tse tloaelehileng tsa tlhaho tse kang acetone le ethyl acetate. Ho tsitsa ha eona tlas'a maemo a fapaneng ho lumella ts'ebeliso ea eona e sebetsang lipatlisisong tsa laboratori le lits'ebetsong tsa indasteri. Tšebeliso ea Ts'ebetso ea Organic: EMTFA e sebetsa e le motheo oa bohlokoa oa ho theha metsoako ea tlhaho, haholo-holo ho kenyelletsoeng ha li-motif tsa trifluoromethylated ka har'a limolek'hule tsa tlhaho. Bokhoni bona bo bohlokoa bakeng sa ho nts'etsapele meriana, lik'hemik'hale tsa temo, le lik'hemik'hale tse ikhethang tse nang le ts'ebetso e ntlafalitsoeng ea baeloji le botsitso ba lik'hemik'hale. Khemistri ea Meriana: Ts'ebelisong ea meriana, EMTFA e sebelisoa e le selelekela sa ho kopanya metsoako e sebetsang ea meriana (APIs) ka lebaka la bokhoni ba eona ba ho fana ka thepa e lakatsehang ea meriana. E bapala karolo ea bohlokoa k'hemistring ea meriana ka ho nolofalletsa phetoho ea limolek'hule tsa meriana ho ntlafatsa katleho le ho fokotsa ho pepesehela metabolism. Lik'hemik'hale tse Ikhethang: EMTFA e fumana ts'ebeliso tlhahisong ea lik'hemik'hale tse ikhethang joalo ka meriana e bolaeang limela, likokoanyana tse bolaeang likokoanyana, le metsoako e rarahaneng e sebelisoang tlhahisong ea lik'hemik'hale tsa temo le lik'hemik'hale tse ntle. Ho feto-fetoha ha eona liphetohong tsa lik'hemik'hale ho e etsa ea bohlokoa mefuteng moo ho hlokahalang taolo e nepahetseng holim'a sebopeho le ts'ebetso ea limolek'hule. Synthesis Ethyl 2-methyl-4,4,4-trifluoroacetoacetate e hlahisoa ka ts'ebetso ea mehato e mengata e qalang ka karabelo ea Claisen condensation ea ethyl trifluoroacetate ka methyl acetate, e lateloa ke esterification tlas'a maemo a laoloang. Karabelo hangata e tsoela pele boteng ba catalyst ea motheo ho nolofalletsa ho thehoa ha β-keto ester. Mekhoa ea ho hloekisa joalo ka distillation kapa recrystallization e sebelisoa ho fumana EMTFA e hloekile haholo e loketseng lits'ebetso tsa indasteri. Mokhoa o bonolo oa synthesis le ho fumaneha ha thepa ea ho qala li kenya letsoho ho theheng ha eona litšenyehelo le ts'ebeliso e pharaletseng lipatlisisong tsa thuto le lits'ebetsong tsa indasteri. Ka bokhutšoanyane, ethyl 2-methyl-4,4,4-trifluoroacetoacetate ke motsoako o feto-fetohang o nang le ts'ebeliso ea bohlokoa tlhahisong ea lintho tse phelang, k'hemistri ea meriana, le tlhahiso ea lik'hemik'hale tse ikhethang. Litšobotsi tsa eona tse ikhethang tsa lik'hemik'hale, ho kenyeletsoa botsitso, ts'ebetso ea ho sebetsa hantle, le bonolo ba tlhahiso, li e beha e le sebapali sa bohlokoa ho ntšetseng pele mahlale a theknoloji makaleng a fapaneng a indasteri le mafapheng a saense.