Boc-Trp-OSu CAS:3392-11-8

Boc-Trp-OSu e bohlokoa haholo k'hemistring ea bioconjugation, haholo-holo ts'ebetsong ea li-peptide le liprotheine bakeng sa lits'ebetso tse reriloeng. Jwalo ka derivative ea NHS ester, e nolofalletsa ho kopanngoa ha covalent ha karolo ea tryptophan e sirelelitsoeng ke Boc le li-amine tsa mantlha tse teng ka har'a li-amino acid, li-peptide, kapa liprotheine. Kopano ena e khethiloeng e lumella phetoho e nepahetseng ea masala a itseng a amino acid ka har'a tatellano ea peptide kapa N-terminus ea protheine, e nolofalletsang ho hlahisoa ha lihlopha tse sebetsang kapa mabitso bakeng sa merero e fapaneng. Bafuputsi le litsebi tsa biochemist ba sebelisa Boc-Trp-OSu nts'etsopele ea li-conjugate tsa peptide bakeng sa lits'ebetso tse kang ho fana ka meriana e reriloeng, liteko tsa immunoassays, le ts'ebetso ea biomaterial. Ka ho kopanya li-peptide tse fetotsoeng ke Boc-Trp-OSu ho limolek'hule kapa libaka tse reriloeng, li ka etsa meaho e sebetsang ea bio e khonang ho sebelisana ka khetho le li-receptor tsa sele, li-antigen, kapa matrices ea baeloji. Ho phaella moo, Boc-Trp-OSu e fumana tshebediso ho lokiseng di-conjugate tsa peptide-protein bakeng sa ho hlahisa di-conjugate tsa antibody-drug (ADCs) le ho ngola mabitso a protheine bakeng sa ditshwantsho le diteko tsa tlhahlobo. Ho feto-fetoha ha Boc-Trp-OSu ho e etsa sesebediswa sa bohlokwa haholo mafapheng a fapaneng a kang baeloji ya dikhemikhale, theknoloji ya baeloji le mahlale a meriana. Ho tsamaellana ha yona le diprothokholo tsa bioconjugation, reactivity e phahameng, le kgetho di tlatsetsa tshebedisong ya yona e pharaletseng dibakeng tsa thuto le tsa indasteri. Ebang e sebediswa dipatlisisong tsa motheo kapa ntshetsopeleng ya kalafo e tswetseng pele, Boc-Trp-OSu e nolofalletsa ho thehwa ha di-conjugate tsa peptide tse ikgethileng tse bohlokwa ho ntshetseng pele kalafo e rerilweng le tlhahlobo ya dimolek'hule.