Boc-Lys(Z)-OSu CAS:34404-36-9

Boc-Lys(Z)-OSu e sebelisoa haholo lits'ebetsong tsa bioconjugation le phetoho ea peptide. Ho hlophisoeng ha peptide, e sebelisoa ho hlahisa masala a lysine libakeng tse itseng ka har'a tatellano ea peptide, e nolofalletsang ho hokela lihlopha tse sebetsang, mabitso, kapa limolek'hule tse ling bakeng sa lits'ebetso tse fapaneng. Phetoho ena e khethiloeng e lumella ho thehoa ha li-peptide tse sebetsang ka bongata tse nang le thepa e etselitsoeng motho ka mong, joalo ka botsitso bo ntlafalitsoeng, ho ikhetha ha sepheo, kapa bokhoni ba ho nka litšoantšo. Ho feta moo, lipatlisisong tsa proteomics, Boc-Lys(Z)-OSu e nolofalletsa ho ngoloa ha liprotheine le li-peptide ka mokhoa o ikhethileng bakeng sa tlhahlobo ea sebopeho, lithuto tsa tšebelisano, le liteko tsa proteomic tse thehiloeng ho mass spectrometry. Ho hokela ho laoloang ha Boc-Lys(Z)-OSu ho masala a lysine ho nolofalletsa tlhaloso e nepahetseng le tlhahlobo ea ts'ebetso ea liprotheine le li-peptide, ka hona ho kenya letsoho tsoelo-peleng ea ho utloisisa litsamaiso tsa baeloji le mekhoa ea mafu. Ho feta moo, lefapheng la ntshetsopele ya meriana, Boc-Lys(Z)-OSu e bapala karolo ya bohlokwa ho kopanyeng di-agent tsa kalafo le di-peptide kapa diprotheine, ka hona e theha ditsamaiso tse reretsweng ho fana ka meriana, di-conjugate tsa di-antibody-drug, kapa meaho ya ente e nang le diprofaele tse ntlafetseng tsa pharmacokinetic le ditlamorao tse fokotsehileng tse sa rerelwang. Ka kakaretso, ho tenyetseha le ho tshepahala ha Boc-Lys(Z)-OSu phetohong ya peptide le bioconjugation ho etsa hore e be sesebediswa sa bohlokwa bakeng sa ho ntshetsa pele dipatlisiso ho sibollong ya meriana, baeloji ya dikhemikhale le proteomics, e fanang ka menyetla e fapaneng ya ho ntshetsa pele ditshebediso tse ntjha tsa bongaka.