Boc-Ile-ONp CAS:16948-38-2

Boc-Ile-ONp e sebelisoa haholo mawa a bioconjugation le lits'ebetsong tsa phetoho ea peptide. Ho kopanyeng peptide, e nolofalletsa ho kenyelletsoa ho laoloang ha masala a isoleucine ka tatellano ea peptide, e nolofalletsang ho hokeloa ho lebisitsoeng ha lihlopha tse fapaneng tsa ts'ebetso, mabitso, kapa limolek'hule bakeng sa lits'ebetso tse fapaneng. Phetoho ena e khethiloeng e lumella ho thehoa ha li-peptide tse sebetsang ka bongata tse nang le thepa e etselitsoeng, joalo ka botsitso bo ntlafalitsoeng, ho ikhetha ha sepheo, kapa bokhoni ba ho nka litšoantšo. Phuputsong ea proteomics, Boc-Ile-ONp e nolofalletsa ho ngoloa ha liprotheine le li-peptide ka ho khetheha sebakeng seo, ho kenya letsoho tlhahlobong ea sebopeho, lithutong tsa tšebelisano, le litekong tse thehiloeng ho spectrometry ea bongata. Ho hokeloa ho laoloang ha Boc-Ile-ONp ho masala a isoleucine ho thusa ho hlalosa ka nepo le tlhahlobo ea ts'ebetso ea liprotheine le li-peptide, ho tšehetsa tsoelo-pele ea ho utloisisa litsamaiso tsa baeloji le mekhoa ea mafu. Ho feta moo, nts'etsopele ea lithethefatsi, Boc-Ile-ONp e bapala karolo ea bohlokoa ho kopanyeng li-agent tsa kalafo le li-peptide kapa liprotheine, ho theha litsamaiso tsa ho fana ka lithethefatsi tse lebisitsoeng, li-conjugate tsa antibody-drug, kapa meaho ea ente e nang le liprofaele tse ntlafalitsoeng tsa pharmacokinetic le litlamorao tse fokotsehileng tse sa lebisitsoeng. Ka kakaretso, botšepehi le ho tenyetseha ha Boc-Ile-ONp phetohong ea peptide le ho kopanya ha bio ho etsa hore e be sesebelisoa sa bohlokoa bakeng sa ho ntšetsa pele lipatlisiso tsa ho sibolloa ha lithethefatsi, baeloji ea lik'hemik'hale le li-proteomics, e fanang ka menyetla e fapaneng ea ho nts'etsapele lits'ebetso tse ncha tsa bongaka.