Bis(2-chloroethyl)aminehydrochloride CAS:821-48-7

Bis(2-chloroethyl)amine hydrochloride e na le ts'ebeliso ea bohlokoa ho oncology le chemotherapy. Jwalo ka moemeli oa alkylating, e sitisa ho ikatisa ha DNA le karohano ea lisele, e leng se etsang hore e be chefo liseleng tse atang ka potlako, ho kenyeletsoa le lisele tsa mofetše. Thepa ena e lebisitse ho nts'etsopele ea li-mustard tsa naetrojene e le li-agent tsa chemotherapeutic bakeng sa ho phekola mafu a fapaneng a neoplastic. E 'ngoe ea ts'ebeliso ea mantlha ea bis(2-chloroethyl)amine hydrochloride ke kalafong ea mefuta e itseng ea mofetše, joalo ka lymphoma, leukemia le lihlahala tse tiileng. Ka ho senya DNA ea lisele tsa mofetše, motsoako ona o ka baka lefu la sele le ho thibela kholo ea hlahala, o thusa ho fokotsa kapa ho felisa bongata bo kotsi liseleng tse amehileng. Ho feta moo, bis(2-chloroethyl)amine hydrochloride e sebelisoa lilaboratoring tsa lipatlisiso ho ithuta mekhoa ea ts'ebetso ea li-agent tsa alkylating le ho hlahloba lits'ebetso tsa tsona tse ka bang teng tsa kalafo. Bo-rasaense ba batlisisa likamano tsa limolek'hule pakeng tsa mustard tsa naetrojene le likarolo tsa sele ho ntlafatsa maano a kalafo ea mofetše le ho nts'etsapele meriana e sebetsang haholoanyane. Ho feta moo, motsoako ona o sebelisoa lithutong tsa pele ho kliniki le litekong tsa kliniki ho lekola katleho ea ona le polokeho ho bakuli ba mofetše. Ka ho hlahloba boemo ba meriana le ts'ebetso ea antitumor ea bis(2-chloroethyl)amine hydrochloride, bafuputsi ba ikemiselitse ho theha karolo ea eona mekhoeng ea sejoale-joale ea oncology le ho ntlafatsa mekhoa ea kalafo bakeng sa mafu a itseng a mofetše. Qetellong, bis(2-chloroethyl)amine hydrochloride e bapala karolo ea bohlokoa kalafong ea mofetše le lipatlisisong tsa bongaka, e fana ka menyetla e mecha ea ho loantša mafu a mofetše le ho ntlafatsa kutloisiso ea rona ea metsoako e loantšang mofetše. Chefo ea eona e khethiloeng liseleng tsa mofetše e totobatsa bohlokoa ba eona nts'etsopele ea mekhoa e mecha ea kalafo bakeng sa ho ntlafatsa liphetho tsa bakuli le boleng ba bophelo.