Avibactam sodium CAS:1192491-61-4

Avibactam sodium e sebelisoa ts'ebetsong ea bongaka e le sethibela-mafu sa beta-lactamase ho tsosolosa katleho ea lithibela-mafu tse itseng khahlanong le libaktheria tse hanyetsanang le meriana e mengata. Hangata e kopantsoe le lithibela-mafu tse kang ceftazidime ho etsa metsoako e tsitsitseng ea tekanyo e shebaneng le mefuta e mengata ea likokoana-hloko tse nang le Gram-negative, ho kenyeletsoa Enterobacteriaceae le Pseudomonas aeruginosa. Bafani ba tlhokomelo ea bophelo ba fana ka lithibela-mafu tse nang le avibactam sodium bakeng sa tšoaetso e rarahaneng ea ka mpeng, tšoaetso ea moroto, pneumonia e fumanoang sepetlele, le tšoaetso e 'ngoe e tebileng ea baktheria e bakoang ke likokoana-hloko tse hanyetsanang le lithibela-mafu tse tloaelehileng. Ho eketsoa ha avibactam sodium ho thusa ho hlola mekhoa ea ho hanyetsa baktheria, ho tsosolosa katleho ea lithibela-mafu ho loantšeng tšoaetso e thata ho e phekola. Mekhoa ea tekanyo e kenyelletsang avibactam sodium e etselitsoe ho latela tšoaetso e itseng, lintlha tsa mokuli, liphetho tsa tlhahlobo ea ho hlaseleha habonolo, le motsoako oa lithibela-mafu o sebelisitsoeng. Ho beha leihlo karabelo ea kalafo haufi-ufi, mekhoa ea ho hlaseleha habonolo ea likokoana-hloko, le litlamorao tse mpe tse ka bang teng ho bohlokoa ho netefatsa liphello tse ntle tsa kalafo le ho fokotsa kotsi ea ho hloleha ha kalafo. Litlamorao tse mpe tse amanang le lithibela-mafu tse nang le sodium ea avibactam li ka kenyelletsa mathata a mala, liketso tsa hypersensitivity, le likotsi tse amanang le tšebeliso ea lithibela-mafu tse tsamaeang le tsona. Bafani ba tlhokomelo ea bophelo ba tlameha ho nahana ka litšobotsi tsa mokuli ka mong le likamano tsa meriana ha ba fana ka metsoako ena ho ntlafatsa katleho le polokeho ea kalafo. Ka ho kopanya avibactam sodium le lithibela-mafu tse loketseng, litsebi tsa tlhokomelo ea bophelo li ka sebetsana ka katleho le tšoaetso ea baktheria e hanyetsanang le meriana e mengata, tsa fa bakuli mekhoa e meng ea phekolo le ho ntlafatsa liphetho tsa kliniki taolong ea mafu a tšoaetsanoang a rarahaneng.