Ansamycin CAS: 72559-06-9

Li-ansamycin, tse kang rifamycins, li sebelisoa hangata mesebetsing ea bongaka ho phekola mafu a fapaneng a baktheria, ho kenyeletsoa lefuba, lepera, le mefuta e itseng ea mafu a staphylococcal le streptococcal. Rifampin, e leng rifamycin e tsebahalang haholo, hangata e sebelisoa e le karolo ea phekolo e kopaneng bakeng sa lefuba le mafu a mang a mycobacterial. Mokhoa oa ts'ebetso ea li-ansamycins o kenyelletsa ho tlama ho RNA polymerase ea baktheria, ka hona ho thibela ho ngoloa ha mongolo 'me qetellong ho lebisa lefung la lisele tsa baktheria. Mokhoa ona o ikhethang oa ts'ebetso o etsa hore li-ansamycin li sebetse hantle khahlanong le mefuta e mengata ea libaktheria tse nang le Gram-positive le Gram-negative. Bafani ba tlhokomelo ea bophelo ba nahana ka hloko ka lintlha tse kang mofuta oa tšoaetso, nalane ea bongaka ea mokuli, le liphetho tsa tlhahlobo ea ho pepesehela baktheria ha ba fana ka li-ansamycins. Tekanyo e nepahetseng, nako ea kalafo, le ho beha leihlo litla-morao tse ka bang teng ke tsa bohlokoa bakeng sa ho eketsa melemo ea phekolo ha ho ntse ho fokotsoa likotsi tse amanang le tšebeliso ea lithibela-mafu. Litla-morao tse mpe tse amanang le li-ansamycins li ka kenyelletsa mathata a mala, chefo ea sebete, le liketso tsa hypersensitivity. Ho beha leihlo khafetsa liteko tsa ts'ebetso ea sebete le ho ela hloko matšoao afe kapa afe a litlamorao tse mpe ho thusa ho netefatsa tšebeliso e sireletsehileng le e sebetsang ea li-ansamycin kalafong ea tšoaetso ea baktheria. Ka kakaretso, li-ansamycin li emela sehlopha sa bohlokoa sa lithibela-mafu tse nang le ts'ebeliso e fapaneng ho laoleng tšoaetso ea baktheria. Ka tšebeliso le tlhokomelo e nepahetseng, litsebi tsa tlhokomelo ea bophelo bo botle li ka sebelisa thepa ea li-ansamycin tse loantšang likokoana-hloko ho loantša tšoaetso ka katleho le ho ntlafatsa liphetho tsa bakuli.