Acetylthiocholine iodide CAS:1866-15-5

Acetylthiocholine iodide e sebediswa haholoholo e le substrate ho lekanya mosebetsi wa enzyme acetylcholinesterase (AChE). AChE e ikarabella bakeng sa ho qhaqha acetylcholine ya neurotransmitter tsamaisong ya methapo. Ho eketswa ha acetylthiocholine iodide motswakong wa karabelo o nang le AChE ho lebisa tlhahisong ya thiocholine le acetate.

Karabelo e ka lemohuwa ka ho eketsa sesupo sa colorimetric kapa fluorometric se arabelang ka ho khetheha le thiocholine. Sekhahla sa tlhahiso ya mmala kapa fluorescence se tsamaellana ka ho toba le mosebetsi wa AChE sampoleng. Sena se etsa hore acetylthiocholine iodide e be sesebediswa sa bohlokwa sa ho lekanya mosebetsi wa AChE disampoleng tse fapaneng tsa baeloji, ho kenyeletswa dinama tse nyane, dikopano tsa sele le madi.

Ho lekanya mosebetsi oa AChE ho sebelisoa acetylthiocholine iodide ho sebelisoa haholo lithutong tsa lipatlisiso tse amanang le litsamaiso tsa cholinergic, mathata a neurodegenerative, le ho pepesehela lik'hemik'hale kapa lithethefatsi tse itseng tse ka amang mosebetsi oa AChE. E ka boela ea sebelisoa e le sesebelisoa sa tlhahlobo bakeng sa ho lemoha li-inhibitor tsa AChE, tse nang le thahasello ntlafatsong ea lithethefatsi bakeng sa mafu a kang Alzheimer's le Parkinson's.

Ntle le ho sebelisoa litekong tsa enzymatic, acetylthiocholine iodide e ka boela ea sebelisoa e le substrate bakeng sa li-biosensor tse thehiloeng ho AChE. Li-biosensor tsena li etselitsoe ho lemoha le ho lekanya boteng ba lintho tse itseng tse ka thibelang ts'ebetso ea AChE, joalo ka chefo e bolaeang likokoanyana ea organophosphate kapa metsoako ea methapo.