Abiraterone CAS:154229-19-3

Abiraterone e sebelisoa haholo-holo ho oncology bakeng sa taolo ea kankere ea prostate e hanyetsanang le metastatic castration (mCRPC). E le thibelo e matla ea androgen biosynthesis, e shebana le enzyme CYP17A1, ea bohlokoa tlhahisong ea testosterone le li-androgen tse ling. Ka ho thibela enzyme ena, abiraterone e hatella tlhahiso ea androgen ka har'a li-testes le ka har'a hlahala ka boeona, ka hona e fokotsa maemo a androgens a khothalletsang kholo ea kankere ea prostate. Ka bongaka, abiraterone e fanoa ka molomo hammoho le prednisone kapa prednisolone ho fokotsa litla-morao tse ka bang teng. Mokhoa ona oa kalafo o bontšitse katleho e kholo ho ntlafatseng sekhahla sa ho phela ka kakaretso le ho liehisa tsoelo-pele ea lefu ho bakuli ba nang le kankere ea prostate e tsoetseng pele ba kileng ba fumana kalafo ea androgen deprivation (ADT). Ho feta moo, tšusumetso ea phekolo ea abiraterone e fetela ka nģ'ane ho mCRPC. Lipatlisiso tse tsoelang pele li hlahloba bokhoni ba eona mehatong ea pele ea kankere ea prostate le hammoho le mekhoa e meng ea phekolo e kang chemotherapy le mekhoa e mecha ea phekolo e shebaneng le eona. Mokhoa oa eona oa tšebetso le melemo ea kliniki li ntse li fuputsoa litekong tse fapaneng tsa kliniki ho ntlafatsa liphetho tsa kalafo le tlhokomelo ea bakuli. Ka bokhutšoanyane, abiraterone e emela ntlha ea bohlokoa phekolong ea mofetše, haholo-holo taolong ea mofetše oa prostate. Bokhoni ba eona ba ho sitisa tlhahiso ea androgen bo fana ka mokhoa o shebaneng le ho phekola lihlahala tse amehang lihormoneng, ho fa bakuli bophelo bo bolelele le boleng bo ntlafetseng ba bophelo. Tsoelo-pele e tsoelang pele le lithuto tsa bongaka li totobatsa karolo ea eona ea bohlokoa ho ntlafatseng maano a kalafo ea mofetše, li tšepisa mekhoa e mecha ea tlhokomelo ea oncology ea motho ka mong.