(6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid CAS:30246-33-4

(6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, e tsejoang hape e le [kenya lebitso la khoebo kapa la kakaretso haeba ho hlokahala], e na le bohlokoa bo boholo lipatlisisong tsa meriana le nts'etsopele ea meriana ka lebaka la thepa ea eona ea lithibela-mafu. Motsoako ona o sebetsa e le motheo oa bohlokoa bakeng sa ho kopanya li-antibacterial agents tse etselitsoeng ho shebana le mefuta e itseng ea baktheria le ho thibela kholo ea tsona. Sebopeho sa eona sa sebopeho se lumella tšebelisano e nepahetseng le li-enzyme tsa baktheria, e sitisa lits'ebetso tsa bohlokoa 'me e lebisa litlamorao tsa ho bolaea baktheria. Ho feta moo, (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid e bapala karolo ea bohlokoa ho loantšeng tšoaetso ea baktheria e behang bophelo bo botle ba batho kotsing. Ka ho kenyelletsa motsoako ona mefuteng ea lithibela-mafu, bafuputsi ba ikemiselitse ho nts'etsapele mekhoa e mecha ea phekolo e nang le katleho e ntlafalitsoeng le khanyetso e fokotsehileng. Mokhoa oa ts'ebetso oa motsoako o shebane le mabota a sele ea baktheria kapa tlhahiso ea protheine, e fanang ka mefuta e mengata ea ts'ebetso khahlanong le libaktheria tse nang le Gram-positive le Gram-negative, ho kenyeletsoa le mefuta e hanyetsanang le meriana e mengata. Ho feta moo, boiteko ba lipatlisiso bo shebane le ho ntlafatsa thepa ea pharmacokinetic ea (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid ho ntlafatsa bioavailability ea eona le kabo ea eona 'meleng. Ts'ebetso ena ea ntlafatso e kenyelletsa ho hlahloba maano a fapaneng a ho fana ka meriana, joalo ka li-prodrugs, nanoparticles, kapa li-liposomal formulations, ho ntlafatsa bokhoni ba kalafo ba motsoako le ho fokotsa litla-morao. Qetellong, (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid e emela letlotlo la bohlokoa lefapheng la kalafo ea mafu a tšoaetsanoang, e fanang ka litharollo tse tšepisang tsa ho sebetsana le ho hanyetsa baktheria le ho ntlafatsa liphetho tsa bakuli. Tšebeliso ea eona e mengata kalafong ea lithibela-mafu e totobatsa bohlokoa ba eona merianang ea sejoale-joale 'me e totobatsa bokhoni ba eona ba ho susumetsa boqapi nts'etsopele ea lithibela-mafu tsa moloko o latelang.