(2R,4S)-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid CAS:132622-78-7

Tšebeliso e nang le mahlakore a mangata ea (2R,4S)-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid e lits'ebetsong tsa eona tse pharaletseng lipatlisisong tsa meriana, k'hemistri ea meriana le ho sibolloa ha lithethefatsi. E le motheo oa kaho ea chiral, e bohlokoa bakeng sa nts'etsopele ea limolek'hule tse ncha tsa tlhaho le bakhethoa ba meriana ba ka bang teng. Bafuputsi ba sebelisa likarolo tsa eona tsa sebopeho ho hlahloba karolo ea eona ho nts'etsopele ea mekhoa ea phekolo e shebaneng le mafu a fapaneng, e leng se ka lebisang ho thehoeng ha lihlahisoa tse ncha tsa meriana tse nang le katleho e ntlafalitsoeng le thepa e ntlafalitsoeng ea pharmacokinetic, e fanang ka melemo e ka bang teng bakeng sa tlhokomelo ea bophelo le meriana. Ho feta moo, motsoako ona o fumana ts'ebeliso ho kopanyeng peptide le k'hemistri ea ho kopanya, e tlatsetsang ho thehoeng ha li-peptidomimetics tse fapaneng le meriana e thehiloeng ho peptide. Tlhaho ea eona ea chiral e etsa hore e be ea bohlokoa bakeng sa tlhahiso ea li-peptide tse itseng tse nang le thepa e etselitsoeng eona, e atolosa boholo ba likhetho tsa kalafo tse fumanehang nts'etsopele ea meriana. Ho phaella moo, (2R,4S)-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid e tshehetsa ho batlisisa dikarabelo tse ntjha tsa dikhemikhale le ntshetsopele ya ditsela tse ntjha tsa maiketsetso, e fa bafuputsi le bo-rakhemisi sesebediswa se feto-fetohang bakeng sa ho theha dibopeho tse ntjha tsa dimolek'hule. Tshebediso ya yona e nang le mahlakore a mangata e totobatsa karolo ya yona ya bohlokwa ho kganneng boiqapelo le kgatelopele ka hara tlhahiso ya manyolo, dipatlisiso tsa meriana, le indasteri e pharaletseng ya dikhemikhale, e fana ka ditsela tse tshepisang bakeng sa ntshetsopele ya dihlahiswa le mahlale a matjha. Ka kakaretso, ditshebediso tse feto-fetohang tsa motsoako ona di o beha e le letlotlo la bohlokwa dipatlisisong tsa mahlale le mesebetsing ya diindasteri.