β-Nicotinamide Mononucleotide CAS: 1094-61-7

β-Nicotinamide mononucleotide (NMN) e sebelisetsoa ho ithuta li-motif tse tlamang ka har'a li-aptamers tsa RNA le mekhoa ea ts'ebetso ea ribozyme e kenyelletsang likaroloana tsa RNA tse entsoeng ke β-nicotinamide mononucleotide (β-NMN).NMN ke nucleotide e nkiloeng ho ribose le nicotinamide.Niacinamide (nicotinamide,) e nkiloeng ho vithamine B3, eo hape e tsejoang e le niacin.) Joaloka selelekela sa biochemical sa NAD+, e ka ba molemo ho thibela pellagra.
β-Nicotinamide mononucleotide ke karolo e bohareng ea biosynthesis ea nicotinamide adenine dinucleotide (NAD+).Nicotinamide phosphoribosyltransferase (Nampt) e etsa hore ho be le condensation ea nicotinamide ka 5-phosphoribosyl-1-pyrophosphate ho hlahisa β-NMN, eo hamorao e fetoloang ho NAD+ ka β-NMN adenyltransferase.At μMN 50-100 e sebelisitsoe ho ntlafatsa NAD biosynthesis le glucose-stimulated insulin secretion ka mofuta oa Nampt+/- mouse oa lefu la metabolism, e bontšang karolo ea Nampt mosebetsing oa β cell.