β-Nicotinamide Adenine Dinucleotide CAS:53-84-9

NAD+ e na le bohlokoa bo boholo mosebetsing oa sele 'me e hapile thahasello masimong a kang lipatlisiso tsa botsofali, metabolism le bophelo bo botle ba sele. Joaloka coenzyme, NAD+ e ameha liketsong tsa redox tse hlokahalang bakeng sa tlhahiso ea matla ka har'a mitochondria, e tšehetsa lits'ebetso tse kang glycolysis, potoloho ea tricarboxylic acid, le phosphorylation ea oxidative. Ho feta moo, NAD+ e sebetsa e le substrate bakeng sa lienzyme tse kang sirtuins le PARPs, tse amehang tokisong ea DNA, taolo ea tlhahiso ea liphatsa tsa lefutso, le litsela tsa karabelo ea khatello ea sele. Lilemong tsa morao tjena, li-precursor tsa NAD+, tse kang nicotinamide riboside (NR) le nicotinamide mononucleotide (NMN), li fumane tlhokomelo e le li-supplement tse ka bang teng ho tšehetsa maemo a NAD+ ka har'a lisele. Lipatlisiso li bontša hore ho boloka maemo a matle a NAD+ ho ka bapala karolo ho biogenesis ea mitochondrial, homeostasis ea metabolism le bophelo bo bolelele. Ka lebaka leo, li-precursor tsa NAD+ li ntse li fuputsoa ka bokhoni ba tsona ba ho fokotsa ho theoha ho amanang le botsofali, ho tšehetsa botsofali bo phetseng hantle, le ho rarolla ho se leka-lekane ha metabolism ho amanang le maemo a kang botenya le lefu la tsoekere. Ho feta moo, NAD+ ke sebaka se nang le thahasello e ntseng e hola lipapaling le fisiolojing ea boikoetliso ka lebaka la ho kenella ha eona metabolismeng ea matla le ts'ebetsong ea mitochondrial. Lithuto tse hlahlobang phetoho ea NAD+ mabapi le ts'ebetso ea boikoetliso, ho hlaphoheloa ha mesifa le bokhoni ba mamello li ntse li tsoela pele, ka litlamorao tse ka bang teng bakeng sa ts'ebetso ea lipapali le ho mamella 'mele. Ka kakaretso, NAD+ le lintho tse tlang pele ho eona li emela sebaka se mafolofolo sa lipatlisiso tsa saense ka lits'ebetso tse ka bang teng tse akaretsang botsofali, bophelo bo botle ba lisele, metabolism le fisioloji ea boikoetliso, tse bontšang sebaka se pharaletseng le se ntseng se fetoha sa lipatlisiso le bohlokoa bo ka bang teng ba kalafo.